Evidence map›Paper›PMID 41739151›Full record

ArticleEuropean child & adolescent psychiatry2026

Symptom-specific links between internalizing problems and functional connectivity in adolescents: a network analysis.

Valerie Karl, Ludvig D Bjørndal, Eira R Aksnes, Irene J E Teulings, Niamh MacSweeney, Dani Beck, Lars T Westlye, Omid V Ebrahimi, Christian K Tamnes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European child & adolescent psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Valerie KarlPROMENTA Research Center, Department of Psychology, University of Oslo, Blindern, PO Box 1094, 0317, Oslo, Norway. valerie.karl@psykologi.uio.no.
Ludvig D BjørndalPROMENTA Research Center, Department of Psychology, University of Oslo, Blindern, PO Box 1094, 0317, Oslo, Norway.
Eira R AksnesPROMENTA Research Center, Department of Psychology, University of Oslo, Blindern, PO Box 1094, 0317, Oslo, Norway.
Irene J E TeulingsPROMENTA Research Center, Department of Psychology, University of Oslo, Blindern, PO Box 1094, 0317, Oslo, Norway.
Niamh MacSweeneyPROMENTA Research Center, Department of Psychology, University of Oslo, Blindern, PO Box 1094, 0317, Oslo, Norway.
Dani BeckPROMENTA Research Center, Department of Psychology, University of Oslo, Blindern, PO Box 1094, 0317, Oslo, Norway.
Lars T WestlyeDepartment of Psychology, University of Oslo, Oslo, Norway.
Omid V EbrahimiPROMENTA Research Center, Department of Psychology, University of Oslo, Blindern, PO Box 1094, 0317, Oslo, Norway.
Christian K TamnesPROMENTA Research Center, Department of Psychology, University of Oslo, Blindern, PO Box 1094, 0317, Oslo, Norway.

Funding

ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$52.0M
ABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5M
Adolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5M
ABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7M
Prospective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2M
ABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7M
ABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9M
FIU-ABCD: Pathways and Mechanisms to Addiction in the Latino Youth of South FloridaU01DA041156 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI Raul Gonzalez, Angela R Laird · 2015 to 2026
$22.8M
ABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3M
ABCD-USA: NYC Research ProjectU01DA041174 · NIDA · YALE UNIVERSITY · PI Arielle Ryan Baskin-Sommers, Betty J Casey · 2015 to 2026
$19.7M
Adolescent Brain Cognitive Development (ABCD) Prospective Research in Studies of Maturation (PRISM) ConsortiumU01DA041117 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LINDA CHANG, THOMAS M ERNST · 2015 to 2026
$19.5M
15/21 ABCD-USA Consortium: Research Project Site at LIBRU01DA050989 · NIDA · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI ROBIN L AUPPERLE, MARTIN P. PAULUS · 2020 to 2026
$14.7M
NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U01 DA050987NIDA NIH HHS U01 DA050988NIDA NIH HHS U01 DA050989NIDA NIH HHS U01 DA051016NIDA NIH HHS U01 DA051018NIDA NIH HHS U01 DA051037NIDA NIH HHS U01 DA051038NIDA NIH HHS U01 DA051039NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147
6 · The paper itself

Abstract

Previous fMRI studies have documented links between internalizing problems in youth and brain functional connectivity of the default (DN), frontoparietal (FP), and salience (SA) networks. Characterized by a large symptom heterogeneity and comorbidity, it remains elusive how individual internalizing symptoms relate to DN, FP, and SA connectivity. Leveraging a large population-based sample of adolescents (N = 2426; mean age = 14.1 years) and an integrated network modelling approach, we identified symptom-specific associations between internalizing problems and functional connectivity and explored sex and timing-specific differences in these links. Our findings revealed small negative associations between self-reported feelings of worthlessness and guilt and DN within-network connectivity and positive associations between fearfulness and FP within-network connectivity. Moreover, sadness and fearfulness were positively associated with DN-SA between-network connectivity. Exploratory analyses revealed no significant sex differences but indicated that DN within-network connectivity around age 10 was negatively associated with self-reported worthlessness at age 14. Our findings show symptom-specific associations between internalizing problems and brain functional circuitry in youth and highlight the complex interplay of symptoms and brain networks.

Indexed as

BrainConnectomeDefault Mode NetworkNerve NetAdolescentChildFemaleHumansMagnetic Resonance ImagingMaleNeural PathwaysABCDFunctional connectivityInternalizing problemsNetwork analysisSymptom networksYouth

Identifiers

PMID41739151
PMCPMC13337947

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.