ArticleAnnals of medicine2026
Comparative burden and projections of chewing tobacco-attributable lip/oral cavity and esophageal cancers: global and China-specific trends, 2000-2036.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Global Burden of Lip and Oral Cavity Cancer Attributed to Different Tobacco Use From 1990 to 2021 and Projection to 2050.International dental journal · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSmokeless tobacco (SLT), particularly chewing tobacco, is an underrecognized public health concern. Its long-term burden and trends, especially in China, remain incompletely quantified.
methodsUsing Global Burden of Disease (GBD) 2021 data, we estimated chewing tobacco-attributable deaths, disability-adjusted life years (DALYs), and age-standardized mortality and DALY rates for lip and oral cavity cancer and esophageal cancer (2000-2021), globally and in China. Analyses were stratified by year, sex, and age. Decomposition, age-period-cohort (APC), and Bayesian age-period-cohort (BAPC) models assessed drivers and project trends.
resultsFrom 2000 to 2021, chewing tobacco-attributable lip and oral cavity cancer deaths and DALYs nearly doubled globally and in China, with modest rises in age-standardized rates. Esophageal cancer showed slight absolute increases but declining standardized rates. For both cancers, DALYs peaked earlier than deaths. Compared with global patterns, China experienced a steeper increase in age-standardized lip and oral cavity cancer burden, particularly among males, and a larger decline in esophageal cancer burden, especially among females, leading to increasing male predominance. Globally, changes mainly reflected population growth and aging, whereas population growth predominated in China. Projections indicate continued increases in lip and oral cavity cancer burden and further declines in esophageal cancer burden.
conclusionsChewing tobacco-attributable lip and oral cavity cancer burden in China has risen markedly and is projected to increase further, particularly among males and working-age populations, whereas esophageal cancer burden continues to decline. Integrated prevention strategies are needed to sustain progress and reduce the growing burden.
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