Evidence map›Paper›PMID 41739223›Full record

ArticleJournal of neurology2026

Measurement properties of the Inflammatory Rasch-built Overall Disability Scale (I-RODS) in patients with Guillain-Barré syndrome.

Farah Pelouto, Nowshin Papri, Juanita A Haagsma, David R Cornblath, Eduardo Nobile-Orazio, Eveline J A Wiegers, Thomas Harbo, Yusuf A Rajabally, Pieter A van Doorn, Kenneth C Gorson and 4 more

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Article in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Farah PeloutoDepartment of Neurology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Nowshin PapriDepartment of Neurology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Juanita A HaagsmaDepartment of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
David R CornblathDepartment of Neurology, Johns Hopkins University, Baltimore, USA.
Eduardo Nobile-OrazioDepartment of Translational Medicine, University of Milan IRCCS Humanitas Clinical Institute, Milan, Italy.
Eveline J A WiegersDepartment of Neurology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Thomas HarboDepartment of Neurology, Aarhus University Hospital, Aarhus, Denmark.
Yusuf A RajaballyAston Medical School, Aston University, Birmingham, UK.
Pieter A van DoornDepartment of Neurology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Kenneth C GorsonNeurology, Tufts University School of Medicine, Boston, USA.
Caroline B TerweeDepartment of Epidemiology and Data Science, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Bart C Jacobs *Department of Neurology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. b.jacobs@erasmusmc.nl.
Mike C Horton *Leeds Psychometric Laboratory for Health Sciences, University of Leeds, Leeds, UK.
IGOS Consortium

Funding

Prinses Beatrix Spierfonds W. OR20-04
6 · The paper itself

Abstract

Guillain-Barré syndrome (GBS) is an acute immune-mediated polyneuropathy with a high disease impact, even after good clinical recovery. The Inflammatory Rasch-built Overall Disability Scale (I-RODS) is a Patient-Reported Outcome Measure (PROM) developed for patients with immune-mediated neuropathies that measures limitations in daily activities and social participation. It consists of 24 items, scored from 0-48. The present study aimed to validate the measurement properties of the I-RODS in patients with GBS included in the prospective International GBS Outcome Study (IGOS). The current study focussed on structural validity, cross-cultural validity, internal consistency, and construct validity of I-RODS using Rasch-based methods. The study was conducted in 1226 patients diagnosed with GBS with a median I-RODS score of 28 (IQR 10-41) 4 weeks after inclusion into IGOS. Rasch analyses revealed adequate internal consistency (PSI = 0.95; α = 0.98) and sufficient construct validity, indicated by strong correlations (R = - 0.91 to - 0.77). Targeting was acceptable, although there was a skew towards the floor (10.1%) and ceiling (9.4%). However, the I-RODS showed poor unidimensionality (12.1% CI 10.7-13.5%) and poor overall fit to the Rasch model. Category thresholds were correctly ordered. Misfit was found in two items. Additionally, 15 of 276 item pairs showed local dependency. While no differential item functioning (DIF) was evident for age or sex, significant DIF by geographic region was observed, with the strongest DIF in one item. These results suggest that the current version of I-RODS could be improved or alternative PROMs for patients with GBS could be developed.

Indexed as

Disability EvaluationGuillain-Barre SyndromePatient Reported Outcome MeasuresActivities of Daily LivingAdultAgedFemaleHumansMaleMiddle AgedProspective StudiesPsychometricsReproducibility of ResultsSeverity of Illness IndexGuillain–Barré syndrome (GBS)Inflammatory Rasch-built Overall Disability Scale (I-RODS)Measurement propertiesPatient-reported outcome measure (PROM)

Identifiers

PMID41739223
PMCPMC12935710

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.