Evidence map›Paper›PMID 41739365›Full record

ArticleLa Radiologia medica2026

Grey matter volume reduction in the cerebellum of hip osteoarthritis patients: insights from pre- and postoperative VBM analysis.

Francesca Caramia, Valentina Calistri, Maddalena Boccia, Alice Teghil, Costanza Giannì, Stefano Gumina, Marco Fiorelli, Alessandro Calistri

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Article in La Radiologia medica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Francesca CaramiaNeuroradiology Unity, Department of Human Neurosciences, University of Rome Sapienza, Viale Dell'Università 30, 00185, Rome, Italy. francesca.caramia@uniroma1.it.ORCID http://orcid.org/0000-0002-8396-1282
Valentina CalistriNeuroradiology Unity, Department of Human Neurosciences, University of Rome Sapienza, Viale Dell'Università 30, 00185, Rome, Italy.
Maddalena BocciaDepartment of Psychology, University of Rome Sapienza, Via Dei Marsi 78, 00185, Rome, Italy.
Alice TeghilDepartment of Psychology, University of Rome Sapienza, Via Dei Marsi 78, 00185, Rome, Italy.
Costanza GiannìNeuroradiology Unity, Department of Human Neurosciences, University of Rome Sapienza, Viale Dell'Università 30, 00185, Rome, Italy.
Stefano GuminaDepartment of Anatomical, Histological, Forensic Medicine and Orthopaedic Science, Sapienza University of Rome, Piazzale A. Moro 3, 00185, Rome, Italy.
Marco FiorelliNeuroradiology Unity, Department of Human Neurosciences, University of Rome Sapienza, Viale Dell'Università 30, 00185, Rome, Italy.
Alessandro CalistriDepartment of Anatomical, Histological, Forensic Medicine and Orthopaedic Science, Sapienza University of Rome, Piazzale A. Moro 3, 00185, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis exploratory study aimed to investigate grey matter (GM) volume changes in patients with hip osteoarthritis undergoing hip joint arthroplasty using voxel-based morphometry (VBM), assessing pre- and postoperative differences and comparing findings with healthy controls (HC). MATERIAL AND

methodsTwenty-one patients with unilateral hip osteoarthritis before and after hip prosthesis insertion (PT group) and 16 HC were studied. All participants were right-handed and free from neurological or psychiatric conditions. Structural T1-weighted MRI scans were acquired at 3 T before and after surgery in the PT group, with an average interval of 112 days, and in the HC group. VBM analyses were conducted using the Computational Anatomy Toolbox (CAT12). Preoperative GM volume differences between PT and HC groups, as well as changes in PT before and after surgery, were analysed using statistical parametric mapping with family-wise error (FWE) correction.

resultsPreoperative comparisons revealed a significant reduction in grey matter volume in the ipsilateral cerebellar Crus II in the PT group compared with HC (pFWE = 0.004). No significant GM volume differences were found between pre- and postoperative assessments in the PT group. Although all patients demonstrated marked clinical improvement at 1-month follow-up, MRI-clinical correlations could not be performed because clinical assessments and postoperative MRI were not acquired at the same time.

conclusionThe findings provide preliminary evidence of cerebellar GM changes in patients requiring hip prostheses, suggesting central nervous system involvement in chronic hip pathology. Interpretation is constrained by the modest sample size and by variability in postoperative imaging intervals. The absence of significant postoperative changes highlights the need for further research to explore the timeline and extent of neuroplastic recovery. These results underscore the importance of considering central adaptations in the management of peripheral joint disorders.

Indexed as

Arthroplasty, Replacement, HipCerebellumGray MatterMagnetic Resonance ImagingOsteoarthritis, HipAgedCase-Control StudiesFemaleHumansMaleMiddle AgedOrgan SizePostoperative PeriodArthroplasty, replacement, HipGray matterMagnetic resonance imagingNeuroplasticityOsteoarthritis, HipVoxel-based morphometry

Identifiers

PMID41739365
PMCPMC13279677

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.