Evidence map›Paper›PMID 41739724›Full record

ArticleObesity facts2026

Visceral, Not Abdominal Subcutaneous, Fat Cell Size Associates with Metabolic Dysfunction-Associated Liver Disease in Severe Obesity.

Eve-Julie Tremblay, Laurent Biertho, Stéfane Lebel, Christian Y Couture, Ina Maltais-Payette, Giada Ostinelli, Marie-Frédérique Gauthier, Fannie Lajeunesse-Trempe, Pascale Mauriège, André Tchernof

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity facts, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eve-Julie TremblayResearch Center of the Quebec Heart and Lung Institute, Laval University, Quebec City, Québec, Canada.
Laurent BierthoResearch Center of the Quebec Heart and Lung Institute, Laval University, Quebec City, Québec, Canada.
Stéfane LebelResearch Center of the Quebec Heart and Lung Institute, Laval University, Quebec City, Québec, Canada.
Christian Y CoutureResearch Center of the Quebec Heart and Lung Institute, Laval University, Quebec City, Québec, Canada.
Ina Maltais-PayetteResearch Center of the Quebec Heart and Lung Institute, Laval University, Quebec City, Québec, Canada.
Giada OstinelliResearch Center of the Quebec Heart and Lung Institute, Laval University, Quebec City, Québec, Canada.
Marie-Frédérique GauthierResearch Center of the Quebec Heart and Lung Institute, Laval University, Quebec City, Québec, Canada.
Fannie Lajeunesse-TrempeResearch Center of the Quebec Heart and Lung Institute, Laval University, Quebec City, Québec, Canada.
Pascale MauriègeResearch Center of the Quebec Heart and Lung Institute, Laval University, Quebec City, Québec, Canada.
André TchernofResearch Center of the Quebec Heart and Lung Institute, Laval University, Quebec City, Québec, Canada, andre.tchernof@criucpq.ulaval.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAdipocyte hypertrophy is an important marker of adipose tissue dysfunction which significantly correlates with cardiometabolic risk factors. Fat cell size increases with adiposity and then plateaus at body mass index (BMI) values higher than 30 kg/m2. It is unknown whether fat cell size still associates with markers of dysmetabolism in severe obesity. Our objectives were to examine the associations between adipocyte diameter and markers of cardiometabolic health in a large sample of participants with severe obesity while adjusting for age, BMI, and waist circumference.

methodsBiopsy samples of liver as well as abdominal subcutaneous and omental adipose tissues were obtained from 337 bariatric surgery patients. Evaluation of histological liver characteristics (steatosis, steatohepatitis, portal and lobular inflammation, hepatocellular ballooning, and hepatic fibrosis) was performed by specialized pathologists. Adipocyte diameters were measured automatically using microscopy imaging. Lipid-lipoprotein profile, glucose-insulin homeostasis, and adipokine levels were measured from blood samples.

resultsOmental fat cell size was significantly larger with the presence of metabolic dysfunction-associated steatotic liver disease, metabolic dysfunction-associated steatohepatitis, liver fibrosis and lobular inflammation, as well as the presence and severity of portal inflammation. When stratified by sex, omental adipocytes were larger in women with liver injury, but not in men.

conclusionIn participants with severe obesity, associations between adipocyte hypertrophy and cardiometabolic risk factors are mostly seen in the omental fat compartment, and especially in women.

Indexed as

Adipocyte hypertrophyCardiometabolic healthMetabolic dysfunction-associated steatotic liver diseaseSevere obesity

Identifiers

PMID41739724
PMCPMC13043179

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.