Evidence map›Paper›PMID 41739759›Full record

ArticlePloS one2026

Conservative management of cervical intraepithelial neoplasia grade 2 and immunohistochemical staining of p16 and Ki-67: Data from a Brazilian institution.

Amanda Leal Ferreira, Yara Lúcia Mendes Furtado de Melo, Elyzabeth Avvad Portari, Dione Corrêa Araújo Dock, Nilma Valéria Ferreira Caldeira, Saint Clair Dos Santos Gomes Júnior, Fabio Bastos Russomano, Cecília Vianna de Andrade

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Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amanda Leal FerreiraLaboratory of Pathology and Cytopathology, Fernandes Figueira National Institute of Women, Child, and Adolescent Health of Fiocruz, Rio de Janeiro, Rio de Janeiro, Brazil.
Yara Lúcia Mendes Furtado de MeloCervical Pathology, Gynecology Institute of the Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Elyzabeth Avvad PortariLaboratory of Pathology and Cytopathology, Fernandes Figueira National Institute of Women, Child, and Adolescent Health of Fiocruz, Rio de Janeiro, Rio de Janeiro, Brazil.
Dione Corrêa Araújo DockLaboratory of Pathology and Cytopathology, Fernandes Figueira National Institute of Women, Child, and Adolescent Health of Fiocruz, Rio de Janeiro, Rio de Janeiro, Brazil.
Nilma Valéria Ferreira CaldeiraLaboratory of Pathology and Cytopathology, Fernandes Figueira National Institute of Women, Child, and Adolescent Health of Fiocruz, Rio de Janeiro, Rio de Janeiro, Brazil.
Saint Clair Dos Santos Gomes JúniorClinical Research Unit, Fernandes Figueira National Institute of Women, Child, and Adolescent Health of Fiocruz, Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-1554-943X
Fabio Bastos RussomanoClinical and Surgical Care of Women's Area, Fernandes Figueira National Institute of Women, Child, and Adolescent Health of Fiocruz, Rio de Janeiro, Rio de Janeiro, Brazil.
Cecília Vianna de AndradeLaboratory of Pathology and Cytopathology, Fernandes Figueira National Institute of Women, Child, and Adolescent Health of Fiocruz, Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0001-7980-4367

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCervical intraepithelial neoplasia grade 2 (CIN2) includes both transient HPV infections and precursor lesions of cervical cancer. Conservative management aims to avoid overtreatment, especially in reproductive-aged women.

objectiveTo describe the clinical outcomes and time to lesion regression among conservatively managed, biopsy-confirmed CIN2 cases, and to explore whether baseline characteristics, including p16 and Ki-67, were associated with lesion regression. MATERIALS AND

methodsAn observational cohort study was conducted in patients with CIN2, as determined by cervical biopsy. Participants were followed up with cytology and colposcopy every 6 months, and outcomes were categorized as regression or no regression. At least two pathologists evaluated p16 immunohistochemical staining according to LAST criteria. Ki-67 staining was considered positive when at least 50% of cells in the lesion were stained, as determined by digital quantification. Bivariate analysis and survival curve analyses were conducted, with significant associations defined as p-values <0.05.

resultsFifty patients with a mean age of 30.5 years were included in the study; 76% (38/50) showed regression. The median time to regression was 357 days (SE = 61.4 days; 95% CI: 236.6-477.4 days). The baseline characteristics, including p16 and Ki-67, were not statistically associated with regression, likely due to the small sample size.

conclusionCIN2 regression occurred in 76% of cases, with median times of approximately 12 months for regression and 32 months for progression. No statistically significant associations were detected between baseline characteristics, including biomarkers, and lesion regression in this exploratory study.

Identifiers

PMID41739759
PMCPMC12935196

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.