Trial reportCardiovascular research2026
A randomized, double-blind, crossover study of acute low-level night-time road traffic noise: effects on vascular function, sleep, and proteomic signatures in healthy adults.
Trial report in Cardiovascular research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- [Noise and the heart].Herz · 2026Review
- The Therapeutic Home Environment for Chronic Diseases: A Transdisciplinary Ecosystem for Achieving Migraine Freedom and Managing Comorbid Anxiety, Insomnia, and Chronic Pain.Healthcare (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
Abstract
aimsRoad traffic noise is the dominant source of environmental noise in Europe and a recognized cardiovascular risk factor, yet direct mechanistic evidence from human studies remains limited. This study investigated the acute effects of low-level night-time road traffic noise exposure on cardiovascular parameters in healthy adults. METHODS AND
resultsIn a randomized, double-blind, crossover design, 74 healthy participants were exposed to three overnight conditions: control (no noise, average sound pressure level (LAeq) 30.70 dB), 30 (LAeq 41.36), and 60 (LAeq 44.13) recorded road traffic noise events (peak level ≈60 dB). The primary endpoint was endothelial function assessed by flow-mediated dilation (FMD) the morning after each night; a subgroup received vitamin C to assess oxidative stress involvement. Secondary endpoints included sleep quality (questionnaires), cardiovascular parameters (blood pressure, heart rate, electrocardiogram), and targeted proteomic analysis (Olink panels). FMD significantly decreased from 9.35% (control) to 8.19% after 30 noise events (Δ = 1.16%, P = 0.005) and 7.73% after 60 events (Δ = 1.63%, P < 0.0001), with the strongest FMD improvement by vitamin C in the 60-event condition (Δ = 1.02%). Noise exposure increased heart rate (mean difference Δ = 1.23 bpm, P = 0.04; max Δ = 7.95 bpm, P < 0.001) and the odds of post-noise heart rate peaks (odds ratio 2.42, 95% confidence interval 2.07-2.83). After noise exposure, self-reported sleep quality and restfulness were significantly impaired across all dimensions. Clinical chemistry blood parameters did not change significantly. Proteomic analysis revealed noise-associated changes in interleukin signalling and chemotaxis in participants with the strongest FMD impairments.
conclusionAcute exposure to night-time road traffic noise leads to measurable changes in cardiovascular health parameters in healthy adults. These effects were linked to activation of molecular pathways of immune signalling. Plasma proteome changes were correlated to FMD changes (responders vs. non-responders), highlighting interindividual biological susceptibility to noise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.