Evidence map›Paper›PMID 41740885›Full record

ArticleJournal of lipid research2026

LPLAT10/LPEAT2 produces atypical phospholipids with an unsaturated FA at the sn-1 position.

Hiroki Kawana, Rikuta Kataoka, Yukitaka Sato, Hirofumi Onishi, Taiga Iwama, Yuta Shimanaka, Daisuke Saigusa, Kuniyuki Kano, Nozomu Kono, Junken Aoki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hiroki KawanaGraduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan; Graduate School of Science and Technology, Nara Institute of Science and Technology, Nara, Japan.
Rikuta KataokaGraduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.
Yukitaka SatoGraduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan.
Hirofumi OnishiGraduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.
Taiga IwamaGraduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.
Yuta ShimanakaGraduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.
Daisuke SaigusaFaculty of Pharmaceutical Sciences, Teikyo University, Itabashi-Ku, Tokyo, Japan.
Kuniyuki KanoGraduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.
Nozomu KonoGraduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.
Junken AokiGraduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan. Electronic address: jaoki@mol.f.u-tokyo.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Major membrane phospholipids (PLs) contain saturated FAs, such as palmitic acid (C16:0) and stearic acid (C18:0), at the sn-1 position. Although atypical PLs containing unsaturated FAs at the sn-1 position exist as minor components, the biosynthetic pathway responsible for their production has remained elusive. Here, we report that LPLAT10 (also known as LPEAT2 or LPCAT4) is a lysophospholipid acyltransferase responsible for generating PLs with an unsaturated FA at the sn-1 position. In vitro, LPLAT10 incorporated both saturated and unsaturated FAs into lysophosphatidylcholine, lysophosphatidylethanolamine, and lysophosphatidylserine, selectively at the sn-1 position. LPLAT10 appeared to have a relatively higher affinity for unsaturated FA-CoAs. Consistently, only PLs with unsaturated FAs such as oleic acid (C18:1), linoleic acid (C18:2), arachidonic acid (C20:4), and DHA (C22:6) at the sn-1 position decreased in the brain from Lplat10-deficient mice. Despite their low abundance, these atypical PLs may have specific roles, given that LPLAT10 is highly expressed in neurons and its encoding genes are highly conserved among vertebrates above fish.

Indexed as

1-Acylglycerophosphocholine O-AcyltransferaseFatty Acids, UnsaturatedPhospholipidsAnimalsHumansMice1-Acylglycerophosphocholine O-AcyltransferaseFatty Acids, UnsaturatedPhospholipidsLand’s cycleLPCAT4LPEAT2LPLAT10lysophospholipidssn-1 positionunsaturated FA

Identifiers

PMID41740885
PMCPMC13051972

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.