ArticleThe European journal of neuroscience2026
The EEG-Indexed Impacts of Caffeine on Auditory Novelty Processing Across Phases of the Human Menstrual Cycle.
Article in The European journal of neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The EEG-Indexed Impacts of Caffeine on Auditory Novelty Processing Across Phases of the Human Menstrual Cycle.The European journal of neuroscience · 2026Article
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Authors and funding
11 authors.
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Abstract
Caffeine, the most used global stimulant, can impact neurocognition. Hormonal fluctuations occurring across the human menstrual cycle affect similar cognitive domains. Research is needed to identify whether the purported cognitive-enhancing effects of caffeine vary across menstrual cycle phase. The objective of this study was to examine the impact of caffeine on EEG-derived markers of auditory change detection and novelty processing (MMN, P3a, P3b and RON) across phases of the menstrual cycle in naturally cycling females. Participants were randomly assigned to complete the experiment while in their menstrual (n = 31), follicular (n = 26) or luteal (n = 29) phase, completing two sessions wherein they were administered either a caffeine pill (200 mg, oral) or a placebo in a counterbalanced order using a randomized, double-blinded procedure. Auditory tone detection was assessed via a novelty oddball task while EEG data were collected. Caffeine significantly enhanced target detection at both the neural (P3b, MMN and RON) and behavioural levels, with effects most prominent in the menstrual phase. Additionally, P3a and P3b amplitudes differed significantly between phase groups under placebo conditions but not under caffeine conditions. Caffeine significantly enhanced target detection at both the electrophysiological and behavioural levels, with these effects mostly limited to the menstrual phase. Additionally, there were significant differences in ERP activity between all menstrual phases under both placebo and caffeine conditions. Our results suggest that caffeine enhances auditory novelty processing, particularly during the menstrual phase, though future research is needed to further explore the intersection of caffeine and the HMC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.