ArticleJournal of animal science2026
Investigating ovarian effects of perfluorooctanoic acid in postpubertal pigs during thermal neutral and heat stress conditions.
Article in Journal of animal science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Heat and chemical stressors: Independent and interactive impacts on the pig ovary.The Journal of reproduction and development · 2026Review
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Authors and funding
6 authors.
Funding
Abstract
Perfluorooctanoic acid (PFOA) is associated with disrupted female endocrine and reproductive function. In this study, the ovarian impact of PFOA exposure was investigated in postpubertal pigs housed in thermal neutral (TN) or heat stress (HS) environments. Gilts (n = 48) were housed in either TN conditions (21.0 ± 0.10 °C) or cyclical HS (32.2 ± 0.1 °C to 26.2 ± 0.1 °C) for 19 days and assigned randomly to TN vehicle control (TC; n = 12), TN PFOA (TP; n = 12, 70 ng PFOA/kg), HS control (HC; n = 12), and HS PFOA (HP; n = 11; 70 ng PFOA/kg) treatments. Relative to TC, ovarian weight was decreased in TP (P = 0.03) and tended to be decreased in HP (P = 0.08). Follicular fluid estradiol tended (P = 0.08) to be decreased in HP relative to HC gilts. Dominant follicle size, vulva size, uterine weight, and follicular fluid progesterone level were not altered by treatment. The number of ovarian primordial, primary, and secondary follicles was not affected by PFOA treatment, but tertiary follicles tended (P = 0.08) to be decreased by HS. In HP gilts, there were more primordial (P = 0.05), secondary (P = 0.002), and empty (P = 0.008) follicles and a tendency for increased primary (P = 0.06) and tertiary (P = 0.08) follicles compared to TC gilts. The abundance of ovarian microsomal epoxide hydrolase (EPHX1) was reduced in HP relative to TC (P = 0.005) and HC (P = 0.006) gilts. In TP gilts, 3β-hydroxysteroid dehydrogenase (3BHSD) was reduced (P = 0.02) and both cytochrome P450 family 19 subfamily A member 1 (CYP19A1) tended (P = 0.06) to be reduced, while 3BHSD tended to be reduced in HP compared to HC gilts (P = 0.09). Thus, there were ovarian impacts of PFOA exposure in TP gilts with some additive impacts in heat-stressed pigs.
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