Evidence map›Paper›PMID 41741574›Full record

ArticleCommunications medicine2026

A genome-wide association study identifies EYA2 as a contributing gene for diabetic retinopathy in type 2 diabetes.

Tengda Cai, Qi Pan, Yiwen Tao, Charvi Nangia, Aravind L Rajendrakumar, Yunyan Ye, Tania Dottorini, Mainul Haque, Colin Na Palmer, Yongqing Shao and 1 more

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Article in Communications medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Tengda CaiNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, China.ORCID http://orcid.org/0000-0003-1617-506X
Qi PanNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, China.
Yiwen TaoNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, China.
Charvi NangiaDivision of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK.
Aravind L RajendrakumarInstitute for Health Equity Research, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yunyan YeDepartment of Ophthalmology, Lihuili Hospital affiliated with Ningbo University, Ningbo, China.
Tania DottoriniDepartment of Infectious diseases, School of Immunology and Microbial Sciences, King's College London, London, UK.
Mainul HaqueSchool of Mathematical Sciences, University of Nottingham Ningbo China, Ningbo, China.
Colin Na PalmerDivision of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK.
Yongqing ShaoDepartment of Ophthalmology, The Affiliated Ningbo Eye Hospital of Wenzhou Medical University, Ningbo, China. sunniesyq@163.com.
Weihua MengNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, China. weihua.meng@nottingham.edu.cn.ORCID http://orcid.org/0000-0001-5388-8494

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetic retinopathy (DR) is a complication of diabetes that affects the eyes. This study aims to identify the genetic variants associated with DR in type 2 diabetes (T2D) patients from the UK Biobank cohort (n = 16,988).

methodsWe conducted a genome-wide association study (GWAS) of DR and integrated genomic results with multi-omics data to identify and prioritize susceptibility variants and genes. The findings are set to undergo validation in four replication cohorts.

resultsHere we show that the lead SNP rs6066146 in EYA2 reaches genome-wide significance (p = 4.21×10

conclusionsOur study demonstrates a genomic risk locus in gene EYA2 associated with DR in type 2 diabetes, which offers deeper insights into broader trait architecture on DR.

Identifiers

PMID41741574
PMCPMC13046729

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.