ArticleNature2026
Human hippocampal neurogenesis in adulthood, ageing and Alzheimer's disease.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Nutritional regulation of gut-brain immune crosstalk across the lifespan.Gut microbes · 2026Review
- Ras-MAPK somatic variants in mesial temporal lobe epilepsy.Current opinion in genetics & development · 2026Review
- Effects of a three-month exercise programme on cognition, mood and neurogenesis: the NeuroFit randomised controlled trial.npj aging · 2026Article
- Reconciling the neurogenic hypothesis of depression with recent advances in adult hippocampal neurogenesis research in humans.Molecular psychiatry · 2026Review
- Exercise and Productive Hippocampal Neurogenesis After Stroke: From Niche Remodeling to Cognitive Recovery.Brain sciences · 2026Review
- Dysregulated adult hippocampal neurogenesis in major depressive disorder.Nature medicine · 2026Article
- Article
- Review
- Anti-Aging Potential of Biogenic Selenium Nanoparticles and Selenium/Polysaccharides Nanoconjugate Biosynthesized byAntioxidants (Basel, Switzerland) · 2026Article
- Neuron-Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Temporal Interference Stimulation Enhances Neural Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Isolation of postnatal human neural stem cells.bioRxiv : the preprint server for biology · 2026Article
- Humanised Environmental Enrichment: Spatial Effects of Cities and Buildings on Adult Hippocampal Neurogenesis in Humans.International journal of molecular sciences · 2026Review
- Harnessing the stem cell potential in the human hippocampus to limit cognitive aging.PLoS biology · 2026Article
- Regulatory Variation at TERT and TERC Shows Limited Association with Early-Onset Alzheimer's Disease in Carriers of the Mexican Founder MutationMedical sciences (Basel, Switzerland) · 2026Article
- Intranasal Anti-CD3 Antibody Treatment Attenuates Post-COVID Neuroinflammation and Enhances Hippocampal Neurogenesis and Cognitive Function in Mice.bioRxiv : the preprint server for biology · 2026Article
- Hippocampal Neurosustainability for Stress Resilience: A Pro-Neurogenic BDNF-Targeted Architectural Enrichment Framework to Overcome Type 2 Allostatic Overload.Brain sciences · 2026Article
- Adult neurogenesis: New neurons, new opportunities.Cell stem cell · 2026Review
Corrections and comments
- Update of
Authors and funding
16 authors.
Ahmed DisoukyDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA.
Mark A SanbornDepartment of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-5308-4680
K R SabithaDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-1679-6694
Mostafa M MostafaDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA.
Ivan Alejandro AyalaMesulam Center for Cognitive Neurology and Alzheimer's disease, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
David A BennettRush Alzheimer's Disease Center, Chicago, IL, USA.
Yisha LuInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Yi ZhouInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0001-6500-8554
C Dirk KeeneUW Biorepository and Integrated Neuropathology (BRaIN) Lab, Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5291-1469
Sandra WeintraubMesulam Center for Cognitive Neurology and Alzheimer's disease, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Tamar GefenMesulam Center for Cognitive Neurology and Alzheimer's disease, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
M-Marsel MesulamMesulam Center for Cognitive Neurology and Alzheimer's disease, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Changiz GeulaMesulam Center for Cognitive Neurology and Alzheimer's disease, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Mark Maienschein-ClineResearch Informatics Core, University of Illinois Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-6619-6788
Jalees RehmanDepartment of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL, USA. jalees@uic.edu.ORCID http://orcid.org/0000-0002-2787-9292
Orly LazarovDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA. olazarov@uic.edu.ORCID http://orcid.org/0000-0002-5887-948X
Funding
Research Education Core FP30AG072977 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Darby Morhardt · 2021 to 2026
$26.3MThe role of PS1 in regulation of adult neurogenesis in the intact and Alzheimer?sR01AG033570 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Orly Lazarov · 2009 to 2026
$5.6MHippocampal neurogenesis in cognitive function and dysfunction in Alzheimer's disease.R01AG076940 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Orly Lazarov · 2022 to 2026
$3.7MHigh-Throughput 3D Multiscale Mass Spectrometry Imaging for Understanding Neurochemical Heterogeneity in Alzheimer's DiseaseR01AG078797 · NIA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Fan Lam, Orly Lazarov · 2022 to 2026
$3.6MPlasticity circuits in Alzheimer s diseaseRF1AG033570 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAZAROV, ORLY · 2020 to 2021
$2.9MMechanisms underlying sporadic Alzheimer's diseaseR01AG060238 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAZAROV, ORLY · 2018 to 2022
$2.4MTraining program in the biology and translational research on Alzheimer's diseaseand related dementiasT32AG057468 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Stephanie M Cologna, Orly Lazarov · 2017 to 2026
$2.3MAcceleration of AD Phenotypes in Asymptomatic Mouse ModelsR01AG062251 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAZAROV, ORLY · 2018 to 2022
$2.2MTraining Program in Personalized Cardiovascular Medicine (TPIPCVM)T32HL139439 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DARBAR, DAWOOD · 2018 to 2022
$2.1MThe role of APP in neurogenesis and AD in Down syndromeRF1AG079002 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAZAROV, ORLY · 2022 to 2022
$2.0MPathogen-induced cellular senescence and blood-brain barrier dysfunction in Alzheimer's DiseaseR01AG091545 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Jalees Rehman · 2025 to 2026
$1.6MThe role of APP in neurogenesis and AD in Down syndromeR01AG079002 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Orly Lazarov · 2025 to 2026
$1.3MNHLBI NIH HHS T32 HL139439NIA NIH HHS F31 AG090005NIA NIH HHS P30 AG072977NIA NIH HHS R01 AG033570NIA NIH HHS R01 AG060238NIA NIH HHS R01 AG062251NIA NIH HHS R01 AG076940NIA NIH HHS R01 AG078797NIA NIH HHS R01 AG079002NIA NIH HHS R01 AG091545NIA NIH HHS R21 AG061628NIA NIH HHS RF1 AG033570NIA NIH HHS RF1 AG079002NIA NIH HHS T32 AG057468
Abstract
The existence of human hippocampal neurogenesis has long been disputed
Indexed as
AgingAlzheimer DiseaseHippocampusNeurogenesisAdultAgedAged, 80 and overAstrocytesCA1 Region, HippocampalChromatinCognitionFemaleHumansMaleMemoryMiddle AgedChromatinTranscription Factors
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.