Evidence map›Paper›PMID 41741653›Full record

ArticleNature2026

A membrane-bound nuclease directly cleaves phage DNA during genome injection.

Daniel S Saxton, Peter C DeWeirdt, Christopher R Doering, Ian J Roney, Michael T Laub

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. How bacterial immune systems sense phage infection.Nature reviews. Microbiology · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daniel S SaxtonDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Peter C DeWeirdtDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Christopher R DoeringDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1608-1020
Ian J RoneyDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-3320-1170
Michael T LaubDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. laub@mit.edu.ORCID http://orcid.org/0000-0002-8288-7607

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

From mammals to bacteria, the direct recognition and cleavage of viral nucleic acids is a potent defence strategy against viral infection, but it requires mechanisms for distinguishing self from non-self

Indexed as

Bacteriophage lambdaDNA, ViralEscherichia coliCell MembraneDNA CleavageEscherichia coli ProteinsGenome, ViralDNA, ViralEscherichia coli Proteins

Identifiers

PMID41741653
PMCPMC13190303

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.