Evidence map›Paper›PMID 41742349›Full record

ArticleThe Pediatric infectious disease journal2026

Impaired Treg Response and Subclinical Cardiac Dysfunction in Children Following SARS-CoV-2 Infection.

Costanza Di Chiara, Anna Cantarutti, Jolanda Sabatino, Domenico Sirico, Francesco Bonfante, Marthe Le Prevost, Danilo Buonsenso, Emma Concetta Manno, Francesco Carmona, Daniele Donà and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Pediatric infectious disease journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Costanza Di ChiaraFrom the Department for Women's and Children's Health, University of Padua, Italy.ORCID 0000-0002-3586-0612
Anna CantaruttiDivision of Biostatistics, Epidemiology and Public Health, Laboratory of Healthcare Research and Pharmacoepidemiology, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy.
Jolanda SabatinoDepartment of Medical and Surgery Sciences, Magna Græcia University, Catanzaro, Italy.
Domenico SiricoFrom the Department for Women's and Children's Health, University of Padua, Italy.
Francesco BonfanteDivision of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Padua, Italy.
Marthe Le PrevostPenta-Child Health Research, Padua, Italy.
Danilo BuonsensoDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Emma Concetta MannoResearch Unit of Clinical Immunology and Vaccinology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Francesco CarmonaImmunology and Diagnostic Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
Daniele DonàFrom the Department for Women's and Children's Health, University of Padua, Italy.
Anita De RossiDepartment of Surgery, Oncology and Gastroenterology, Section of Oncology and Immunology, University of Padova, Padua, Italy.
Giovanni Di SalvoFrom the Department for Women's and Children's Health, University of Padua, Italy.
Maria Raffaella PetraraImmunology and Diagnostic Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
Carlo GiaquintoFrom the Department for Women's and Children's Health, University of Padua, Italy.

Funding

European Union 101045989
6 · The paper itself

Abstract

In a preliminary cohort of children recovering from asymptomatic or mild coronavirus disease 2019, subclinical cardiac contractility alterations were associated with reduced regulatory T cells, shorter telomeres and elevated inflammatory markers 3 months post-infection. These findings suggest that immune dysregulation may contribute to silent post-coronavirus disease 2019 cardiac dysfunction and warrant confirmation in larger cohorts with long-term follow-up.

Indexed as

COVID-19Heart DiseasesPost-Acute COVID-19 SyndromeT-Lymphocytes, RegulatoryAdolescentChildChild, PreschoolEchocardiographyFemaleHumansMalecardiac contractility alterationschildrenimmune profilepost-COVIDspeckle-tracking echocardiography

Identifiers

PMID41742349
PMCPMC13232696

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.