ReviewBreast cancer (Dove Medical Press)2026
The Role of Actin-Binding Proteins in Breast Cancer Progression.
Review in Breast cancer (Dove Medical Press), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Mechanisms of actin-binding proteins in glycolysis-cytoskeleton coupling.Journal of translational medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Actin and actin-binding proteins (ABPs) regulate fundamental processes in cancer progression, including migration, invasion, and metastasis. Despite increasing evidence from in vitro and in vivo studies, the role and prognostic significance of actin and ABPs in breast cancer remain unclear due to the lack of a comprehensive review. This review, conducted in 2024 following PRISMA 2020 guidelines, systematically searched PubMed and Scopus using MeSH terms and text words to identify English-language original studies on actin and actin-binding proteins (ABPs) in breast cancer progression. Inclusion criteria were applied during title/abstract screening and full-text review, focusing on studies reporting cell migration, invasion, or metastasis. A total of 176 studies were included, comprising in vitro and in vivo models that investigated ABPs such as Fascin, Cofilin, and Mena, along with key signaling pathways like Rho GTPase, PI3K, and MAPK/ERK. Extracted data included cell lines, interventions, signaling pathways involved in actin or ABP regulation, the mechanism by which each intervention impacted actin remodeling or ABP expression, and outcomes such as migration, invasion, or metastasis. Prominent ABPs such as fascin, cofilin, and Mena were found to influence actin cytoskeletal dynamics, cell motility, and metastatic behavior. Findings highlight the prognostic relevance of ABPs and their therapeutic potential, although clinical translation remains limited by biological complexity and lack of standardized detection tools.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.