ReviewInternational journal of dentistry2026
Effects of Nutritional Supplements Alone or as an Adjunct to Nonsurgical Periodontal Therapy: A Systematic Review and Network Meta-Analysis.
Review in International journal of dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effects of Nutritional Supplements Alone or as an Adjunct to Nonsurgical Periodontal Therapy: A Systematic Review and Network Meta-Analysis.International journal of dentistry · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Nutritional supplements (NSs) have been introduced as an adjunct to nonsurgical periodontal therapy (NSPT) in recent years. The aim of the present study was to evaluate the clinical effectiveness of NSs as an adjunct to NSPT by a network meta-analysis (NMA). Methods: This study followed the PRISMA guidelines, and its protocol was registered with PROSPERO. We searched PubMed, Embase, Web of Science, and Cochrane Library for relevant studies. Gingival index (GI), plaque index (PI), probing pocket depth (PPD), clinical attachment level (CAL), and bleeding on probing (BOP) were selected as outcomes. A comparative analysis of different interventions was performed by using a Bayesian NMA model. Quality assessment was performed using the RoB2.0 tool. Results: Seventy-nine studies were included, with seven types of NSs. Herbal antioxidants were the most effective in reducing BOP. VD and antioxidants + scaling and root planing (SRP) exhibited significant efficacy on alleviating CAL at 3-month (3 m) and 6-month (6 m) follow-up. Additionally, herbal-antioxidants + SRP, probiotic + SRP, and melatonin demonstrated good efficacy on ameliorating PI, GI, and PPD. Conclusions: Among the seven types of NSs identified in this NMA, some NSs exhibit relatively higher periodontal health benefits. However, evidence regarding the effectiveness of NSs as an adjunct to NSPT is still insufficient and warrants further high-quality clinical trials.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.