Evidence map›Paper›PMID 41743360›Full record

ArticleClinical case reports2026

Hidden Drug Rash With Eosinophilia and Systemic Symptoms (DRESS): A Rare Case of Preceding Organ Damage Before Skin Manifestations.

Kent Sato, Satoshi Kawaguchi, Shunsuke Nakajima, Akihito Tampo, Motoi Okada

Abstract read
In one paragraph

Article in Clinical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kent SatoDepartment of Emergency Medicine Asahikawa Medical University Asahikawa Japan.
Satoshi KawaguchiDepartment of Emergency Medicine Asahikawa Medical University Asahikawa Japan.
Shunsuke NakajimaDepartment of Emergency Medicine Asahikawa Medical University Asahikawa Japan.
Akihito TampoDepartment of Emergency Medicine Asahikawa Medical University Asahikawa Japan.
Motoi OkadaDepartment of Emergency Medicine Asahikawa Medical University Asahikawa Japan.ORCID https://orcid.org/0000-0003-3779-6703

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug rash with eosinophilia and systemic symptoms (DRESS) is a drug-induced hypersensitivity reaction that can cause significant organ injury. Unlike anaphylaxis, it often goes unnoticed because the skin eruptions develop slowly. We report the case of a 75-year-old woman who presented with eosinophilia and acute kidney injury. Two weeks earlier, she had been treated with minocycline hydrochloride for a giant liver cyst. No rash was initially observed, but by the third day of admission, a widespread eruption appeared. She was diagnosed with minocycline-induced DRESS and treated with oral prednisolone, which was tapered after hemodialysis was discontinued. She was later transferred back to her previous hospital for rehabilitation. This case highlights that many drugs can trigger DRESS syndrome and that serious organ damage may precede the onset of rash. Clinicians should remain alert to this possibility when evaluating patients with unexplained organ dysfunction.

Indexed as

acute kidney injuryallergyDIHSDRESSdrug‐induced hypersensitivity syndromeminocycline

Identifiers

PMID41743360
PMCPMC12929649

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.