ArticleEcology and evolution2026
Evolutionary History of the Adult β-Globin Gene in Wild Sheep: First Sequences From the Argali (
Article in Ecology and evolution, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The β-globin gene cluster is a key model for studying molecular adaptation and gene family evolution in vertebrates, exhibiting dynamic duplication and deletion events in ruminants, particularly within the subfamily Caprinae. However, the complete nucleotide sequences of the adult β-globin gene remain unknown for several ecologically important wild sheep species, such as the Argali and the Urial, hindering robust phylogenetic and adaptive studies. Genomic DNA was extracted from wild Argali and Urial samples, and the full coding region of the adult β-globin gene was sequenced and compared against a comprehensive dataset of Bovidae and Cervidae. Sequence comparison confirmed high divergence between paralogous genes (HBBA and HBBB), and critically, revealed that Argali hosts two distinct adult β-globin haplotypes, one harboring a HBBA gene and the other a HBBB gene. Phylogenetic analysis revealed that sequences clustered consistently by paralog type (HBBA vs. HBBB) with both the Caprinae and Bovinae lineages. This pattern suggests independent evolutionary trajectories for each paralog, likely driven by concerted evolution. Molecular dating estimated the duplication event leading to the HBBA/HBBB paralogs in Caprinae at approximately 2.55 million years ago, supporting a rapid, recent diversification of the β-globin cluster in
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.