ArticleJournal of ophthalmology2026
Reducing the Carbon Footprint of Neovascular Age-Related Macular Degeneration Therapy: Environmental Impact of Transitioning to Aflibercept 8 mg.
Article in Journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Reducing the Carbon Footprint of Neovascular Age-Related Macular Degeneration Therapy: Environmental Impact of Transitioning to Aflibercept 8 mg.Journal of ophthalmology · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To quantify and compare the carbon footprint associated with neovascular age-related macular degeneration (nAMD) treatment using real-world intravitreal aflibercept 2-mg injections versus a simulated aflibercept 8-mg regimen with extended dosing intervals. Methods: A life cycle assessment (LCA) combining process-based and input-output methodologies was conducted using real patient data from a tertiary ophthalmic center. The analysis included 101 patients treated with aflibercept 2 mg and modeled the environmental impact of transitioning to aflibercept 8 mg. The simulated aflibercept 8-mg cohort was generated by replicating the demographic and logistical characteristics of the real-world aflibercept 2-mg population while applying extended dosing intervals. Emissions were estimated in CO Results: Patients treated with aflibercept 2 mg generated an average carbon footprint of 1150 kg CO Conclusions: A transition from conventional aflibercept 2-mg therapy to an aflibercept 8-mg regimen with extended dosing intervals reduces the treatment's carbon footprint by over one-third. These findings support the integration of environmental considerations into therapeutic decisions in ophthalmology, particularly for high-frequency procedures, such as intravitreal injections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.