ReviewFrontiers in immunology2026
Preclinical exploration and current clinical applications of immunotherapeutic strategies for hepatocellular carcinoma.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Mining and experimental validation of machine learning-based immune-related diagnostic biomarkers for hepatocellular carcinoma.Journal of gastrointestinal oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of cancer death worldwide. Treatment of HCC has shifted from traditional modalities to immunotherapy-centered combination strategies. While the current immunotherapies can substantially reduce the risk of death for patients with HCC, overall survival improvement is limited because of tumor heterogeneity and an immunosuppressive microenvironment. Moreover, the widespread application of these treatments is challenged by high costs, drug resistance, and frequent adverse events. This review outlines the mechanisms of the available HCC immunotherapeutics and summarizes the preclinical explorations of these treatments. We also describe the current clinical applications and underlying mechanisms and discuss issues of resistance and heterogeneity. We further provide an overview of emerging approaches against cancer platforms in HCC, aiming to provide practical references for clinical immunotherapy of HCC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.