Evidence map›Paper›PMID 41743804›Full record

ArticleEnvironment & health (Washington, D.C.)2026

Urinary Organophosphate Esters and Increased Oxidative Stress in Healthy Older Adults: The China BAPE Study.

Chenfeng Li, Xiaojie Guo, Huimin Ren, Yibo Xu, Jianlong Fang, Peijie Sun, Enmin Ding, Yifu Lu, Chenlong Li, Ximiao Zhao and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment & health (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Chenfeng LiChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Xiaojie GuoChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Huimin RenChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Yibo XuChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Jianlong FangChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health Chinese Center for Disease Control and Prevention, Beijing 100021, China.ORCID https://orcid.org/0000-0003-4716-390X
Peijie SunChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Enmin DingChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Yifu LuChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health Chinese Center for Disease Control and Prevention, Beijing 100021, China.ORCID https://orcid.org/0000-0002-2563-8030
Chenlong LiChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Ximiao ZhaoChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Keke LongChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Kangning CaoChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Jiankun QianChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Yuanyuan ChenChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Yu WangChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Fuchang DengChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Minmin HouState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Science, Chinese Academy of Sciences, Beijing 100085, China.ORCID https://orcid.org/0000-0002-2570-9468
Yali ShiState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Science, Chinese Academy of Sciences, Beijing 100085, China.ORCID https://orcid.org/0000-0001-9946-1525
Yaqi CaiState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Science, Chinese Academy of Sciences, Beijing 100085, China.ORCID https://orcid.org/0000-0002-2805-5535
Shilu TongChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Tong ShenSchool of Public Health, Anhui Medical University, Hefei, Anhui 230032, China.ORCID https://orcid.org/0000-0003-1299-106X
Song TangChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health Chinese Center for Disease Control and Prevention, Beijing 100021, China.ORCID https://orcid.org/0000-0003-3219-1422
Xiaoming ShiChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health Chinese Center for Disease Control and Prevention, Beijing 100021, China.ORCID https://orcid.org/0000-0002-7071-571X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exposure to organophosphate esters (OPEs) is associated with the development of geriatric diseases. However, the impact of OPEs on oxidative stress, a precursor of geriatric diseases, remains unclear in older adults. Based on the China BAPE study, a panel study with multiple repeated measurements, we collected urine samples from 76 healthy older adults to measure OPEs and oxidative stress markers, aiming to investigate both individual and combined OPE exposures in relation to oxidative stress. Our results indicated that Dibutyl phosphate (DBP), Bis-(2-ethylhexyl) phosphate (BEHP), Bis-(1,3-dichloro-2-propyl) phosphate (BDCIPP), Diphenyl phosphate (DPHP), and Bis-(2-methylphenyl) phosphate (BMPP) exposure were significantly associated with increased levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), 8-hydroxyguanosine (8-OHG), and malondialdehyde (MDA). Household heating status had a modifying effect on these associations. Generalized additive mixed models revealed potential linear and nonlinear associations between OPEs and oxidative stress markers. The quantile g-computation and Bayesian kernel machine regression further found positive effects of OPEs mixtures on 8-OHdG, 8-OHG, and MDA. Weighted distribution analyses identified BEHP as a potentially contributing component affecting oxidative stress. These findings not only illuminate the health hazards of OPE exposures but also aid in understanding the link between OPEs and adverse health outcomes in older adults.

Indexed as

mixture exposureolder adultsorganophosphate estersoxidative stresspanel study

Identifiers

PMID41743804
PMCPMC12930313

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.