Evidence map›Paper›PMID 41743988›Full record

ArticlebioRxiv : the preprint server for biology2026

Immunoregulatory gene

Chen Xiang, Kaja Arusha, Danielle Springer, Sachiko Nakamori, Ping Du Jiang, Zhi-Hong Yang, Jing Cui, Yu Zhang, Huie Jing, Ann Y Park and 18 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Chen XiangMolecular Development of the Immune System Section, Laboratory of Immune System Biology, Intramural Research Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD, USA.
Kaja ArushaHuman Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Intramural Research Program National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD, USA.
Danielle SpringerMurine Phenotyping Core, Intramural Research Program, National Heart, Lung, and Blood Institute; Bethesda, MD, USA.
Sachiko NakamoriMurine Phenotyping Core, Intramural Research Program, National Heart, Lung, and Blood Institute; Bethesda, MD, USA.
Ping Du JiangMolecular Development of the Immune System Section, Laboratory of Immune System Biology, Intramural Research Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD, USA.
Zhi-Hong YangLipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, Intramural Research Program, National Heart, Lung, and Blood Institute, National Institutes of Health; Bethesda, MD, USA.
Jing CuiMolecular Development of the Immune System Section, Laboratory of Immune System Biology, Intramural Research Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD, USA.
Yu ZhangHuman Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Intramural Research Program National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD, USA.
Huie JingHuman Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Intramural Research Program National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD, USA.
Ann Y ParkMolecular Development of the Immune System Section, Laboratory of Immune System Biology, Intramural Research Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD, USA.
Maria H ZhuMolecular Development of the Immune System Section, Laboratory of Immune System Biology, Intramural Research Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD, USA.
Sarah E WeberMolecular Development of the Immune System Section, Laboratory of Immune System Biology, Intramural Research Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD, USA.
Deniz CagdasDivision of Immunology, Department of Pediatrics, Hacettepe University Faculty of Medicine; Ankara, Turkey.
Hassan AbolhassanResearch Center for Immunodeficiencies, Pediatrics Center of Excellence, Childreńs Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Nasrin BehniafardChildren Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Margery G SmelkinsonBiological Imaging Section, Research Technologies Branch, Intramural Research Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD, USA.
Qihui LiangLaboratory of Biochemistry and Molecular Biology, Intramural Research Program, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA.
Elif EverestTranslational Neuroradiology Section, Intramural Research Program, National Institute of Neurological Disorders and Stroke, National Institutes of Health; Bethesda, MD, USA.
Julia F KunLipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, Intramural Research Program, National Heart, Lung, and Blood Institute, National Institutes of Health; Bethesda, MD, USA.
Alyssa GroganCVPath Institute Inc.; Gaithersburg, MD, USA.
Jennifer D TreatImmunopathogenesis Section, Intramural Research Program, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD, USA.
Christa S ZerbeClinical Genomics Program, Intramural Research Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD, USA.
Steven M HollandClinical Genomics Program, Intramural Research Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD, USA.
Renu VirmaniCVPath Institute Inc.; Gaithersburg, MD, USA.
Alan T RemaleyLipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, Intramural Research Program, National Heart, Lung, and Blood Institute, National Institutes of Health; Bethesda, MD, USA.
Helen C SuHuman Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Intramural Research Program National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD, USA.
Lixin ZhengMolecular Development of the Immune System Section, Laboratory of Immune System Biology, Intramural Research Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD, USA.
Michael J LenardoMolecular Development of the Immune System Section, Laboratory of Immune System Biology, Intramural Research Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Controlling hyperlipidemia has reduced but not eliminated atherosclerotic cardiovascular disease as a predominant cause of human mortality. Here, we report that loss of the immunoregulatory gene GTPase of immunity-associated protein 6 (

Indexed as

cardiovascularFoam cellsinflammationmyocardial Infarction

Identifiers

PMID41743988
PMCPMC12930435

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.