Evidence map›Paper›PMID 41744069›Full record

Trial reportHypertension (Dallas, Tex. : 1979)2026

Intensive BP Control and Cognitive Function: A Randomized Clinical Trial.

Bin Wang, Ying Sun, Yan Li, Liyong Wu, Yue Peng, Shitian Li, Jinzhuo Ge, Liping Zhang, Lingshan Zhao, Jiangling Liu and 9 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Hypertension (Dallas, Tex. : 1979), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04030234 (Effects of Intensive Systolic Blood Pressure Lowering Treatment in Reducing RIsk of Vascular evenTs), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04030234 nacompletednot on this map

Effects of Intensive Systolic Blood Pressure Lowering Treatment in Reducing RIsk of Vascular evenTs (ESPRIT) Study

TypeinterventionalSponsorChina National Center for Cardiovascular DiseasesRan2019 to 2023Enrolled11,255ConditionsHypertensionArmsIntensive BP treatment group, Standard BP treatment group
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Recent developments and challenges in hypertensive dementia over the past year.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Bin Wang *National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, China (B.W., Y.S., Y. Li, Y.P., S.L., J.G., L. Zhang, L. Zhao, Jiangling Liu, H.Z., Jiamin Liu, Jing Li).ORCID 0000-0002-5386-4975
Ying Sun *National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, China (B.W., Y.S., Y. Li, Y.P., S.L., J.G., L. Zhang, L. Zhao, Jiangling Liu, H.Z., Jiamin Liu, Jing Li).
Yan LiNational Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, China (B.W., Y.S., Y. Li, Y.P., S.L., J.G., L. Zhang, L. Zhao, Jiangling Liu, H.Z., Jiamin Liu, Jing Li).
Liyong WuDepartment of Neurology (L.W.), Xuanwu Hospital, Capital Medical University, Beijing, China.
Yue PengNational Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, China (B.W., Y.S., Y. Li, Y.P., S.L., J.G., L. Zhang, L. Zhao, Jiangling Liu, H.Z., Jiamin Liu, Jing Li).ORCID 0009-0002-3840-7677
Shitian LiNational Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, China (B.W., Y.S., Y. Li, Y.P., S.L., J.G., L. Zhang, L. Zhao, Jiangling Liu, H.Z., Jiamin Liu, Jing Li).
Jinzhuo GeNational Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, China (B.W., Y.S., Y. Li, Y.P., S.L., J.G., L. Zhang, L. Zhao, Jiangling Liu, H.Z., Jiamin Liu, Jing Li).ORCID 0000-0002-9765-7935
Liping ZhangNational Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, China (B.W., Y.S., Y. Li, Y.P., S.L., J.G., L. Zhang, L. Zhao, Jiangling Liu, H.Z., Jiamin Liu, Jing Li).
Lingshan ZhaoNational Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, China (B.W., Y.S., Y. Li, Y.P., S.L., J.G., L. Zhang, L. Zhao, Jiangling Liu, H.Z., Jiamin Liu, Jing Li).
Jiangling LiuNational Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, China (B.W., Y.S., Y. Li, Y.P., S.L., J.G., L. Zhang, L. Zhao, Jiangling Liu, H.Z., Jiamin Liu, Jing Li).
Shuhong SuDepartment of Neurology and China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University (J.G.).
Bin ZhangDepartment of Geriatrics Medicine, Xinxiang Central Hospital, Henan, China (S.S.).
Yaqin LiuDepartment of Research and Education, Hegang Hekuang Hospital Co., Ltd., Heilongjiang, China (Y. Liu).
Xiaowen MaDepartment of Cardiology, People's Hospital of Qinyang City, Henan, China (X.M.).
Zhaokai ZuoCardiovascular Ward One, The Second People's Hospital of Liaocheng, Shandong, China (Z.Z.).ORCID 0009-0005-8549-703X
Haibo ZhangNational Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, China (B.W., Y.S., Y. Li, Y.P., S.L., J.G., L. Zhang, L. Zhao, Jiangling Liu, H.Z., Jiamin Liu, Jing Li).ORCID 0000-0001-6153-5568
Yang WangMedical Research & Biometrics Center, National Center for Cardiovascular Diseases, Fuwai Hospital, Beijing, China (Y.W.).
Jiamin LiuNational Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, China (B.W., Y.S., Y. Li, Y.P., S.L., J.G., L. Zhang, L. Zhao, Jiangling Liu, H.Z., Jiamin Liu, Jing Li).ORCID 0009-0005-1192-2726
Jing LiNational Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, China (B.W., Y.S., Y. Li, Y.P., S.L., J.G., L. Zhang, L. Zhao, Jiangling Liu, H.Z., Jiamin Liu, Jing Li).ORCID 0000-0002-8840-8638

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe impact of intensive blood pressure (BP) control on cognitive function in East Asian populations remains uncertain. We aimed to assess the effect of a lower systolic BP target on global cognitive function in Chinese hypertensive adults.

methodsThis secondary analysis of a randomized trial involved hypertensive patients with high cardiovascular risk across 116 sites in China. Participants were assigned to receive intensive treatment (systolic BP target <120 mm Hg) or standard treatment (systolic BP target <140 mm Hg) for a median of 3.4 years. Cognitive function was assessed via MMSE (Mini-Mental State Examination) at baseline and the end of the study. Prespecified outcomes were a change in MMSE score and investigator-reported probable dementia.

resultsAmong 11 255 randomized participants, all completed cognitive assessment at baseline and 10 440 (92.8%) at the end of the study. The mean change in MMSE score was not significantly different between arms (difference, 0.05 [95% CI, -0.07 to 0.17]), with a mean change of -0.54 (95% CI, -0.63 to -0.46) in the intensive arm and -0.60 (95% CI, -0.68 to -0.51) in the standard arm. Results were robust across sensitivity analyses and consistent across most subgroups. Exceptions included subgroups of coronary heart disease or antiplatelet treatment. The incidence of probable dementia was too low for meaningful interpretation.

conclusionsIntensive systolic BP lowering to a target of <120 mm Hg for 3 years did not adversely affect global cognitive function in Chinese hypertensive adults, irrespective of age, sex, BP level, and comorbidities, affirming the cognitive safety of this treatment strategy. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04030234.

Indexed as

Antihypertensive AgentsBlood PressureCognitionHypertensionAgedChinaFemaleHumansMaleMiddle AgedAntihypertensive Agentsblood pressurecognitionevidence gapincidencepublic health

Identifiers

PMID41744069
PMCPMC13001897

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.