Evidence map›Paper›PMID 41744123›Full record

ArticleJournal of the American Heart Association2026

Sex Differences in Young Adult Stroke Severity Using Linked Colorado-All Payer's Claims Database and the Get With The Guidelines-Stroke Registry.

Michelle H Leppert, Sharon Scarbro, Marcelo C Perraillon, Virgina J Howard, Eliza C Miller, Remy Poudel, Kathie Thomas, Shen Li, Krithika Suresh, Lynda Lisabeth and 7 more

Abstract readComparative Study
In one paragraph

Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Journal of the American Heart Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Michelle H LeppertDepartment of Neurology University of Colorado School of Medicine Aurora CO USA.ORCID 0000-0002-0679-7634
Sharon ScarbroRocky Mountain Prevention Research Center Colorado School of Public Health Aurora CO USA.
Marcelo C PerraillonColorado Comprehensive Cancer Center University of Colorado Aurora CO USA.
Virgina J HowardDepartment of Epidemiology School of Public Health, University of Alabama at Birmingham Birmingham AL USA.ORCID 0000-0003-4912-9975
Eliza C MillerDepartment of Neurology University of Pittsburgh Medical Center Pittsburgh PA USA.ORCID 0000-0002-7108-8906
Remy PoudelAmerican Heart Association Dallas TX USA.ORCID 0009-0008-2028-8773
Kathie ThomasAmerican Heart Association Dallas TX USA.ORCID 0009-0006-1692-3282
Shen LiAmerican Heart Association Dallas TX USA.ORCID 0000-0001-9322-6516
Krithika SureshDepartment of Biostatistics School of Public Health, University of Michigan Ann Arbor MI USA.ORCID 0000-0001-7785-3536
Lynda LisabethDepartment of Epidemiology School of Public Health, University of Michigan Ann Arbor MI USA.ORCID 0000-0001-5539-5933
Jukka PutaalaDepartment of Neurology Helsinki University Hospital and University of Helsinki Helsinki Finland.ORCID 0000-0002-6630-6104
Lee SchwammDepartment of Neurology Yale University New Haven CT USA.ORCID 0000-0003-0592-9145
Stacie L DaughertyColorado Cardiovascular Outcomes Research Consortium (CCOR) Aurora CO USA.ORCID 0000-0001-8969-566X
Cathy J BradleyColorado Comprehensive Cancer Center University of Colorado Aurora CO USA.ORCID 0000-0001-9429-6567
James F BurkeDepartment of Neurology The Ohio State University Columbus OH USA.ORCID 0000-0002-2296-1588
P Michael HoColorado Cardiovascular Outcomes Research Consortium (CCOR) Aurora CO USA.ORCID 0000-0002-7775-6266
Sharon N PoissonDepartment of Neurology University of Colorado School of Medicine Aurora CO USA.ORCID 0000-0002-7162-4043

Funding

The Impact of Telestroke on Patterns of Care and Long-Term OutcomesR01NS111952 · NINDS · HARVARD MEDICAL SCHOOL · PI MEHROTRA, ATEEV · 2019 to 2023
$2.4M
NINDS NIH HHS R01 NS111952
6 · The paper itself

Abstract

backgroundMore young women than men experience first-time strokes. This may be from improved detection of milder severity strokes in young women, as they are more likely to present with nondebilitating neurologic symptoms than men.

methodsThe objective was to examine sex differences in stroke severity among young adults. Young adults (18-55) with index stroke (January 1, 2012-April 3, 2019) were identified, using Colorado All Payer's Claims Database and linked to the GWTG (Get With The Guidelines)-Stroke Registry. Records were reviewed based on 5/5 linked identifiers (±1 day for admission/discharge dates, date of birth, sex, and hospital), then on 4/5 linked identifiers. Stroke severity based on National Institutes of Health Stroke Scale score was extracted from GWTG-stroke. Logistic regression models were used to calculate odds ratios (OR) of having a mild severity stroke (National Institutes of Health Stroke Scale score ≤5) by sex in ages 18 to 45 and 46 to 55 years.

resultsColorado All Payer's Claims Database captured 3029 stroke cases; 2732 from hospitals that reported to GWTG-Stroke; 1597 (58.7%) linked at least 4/5 identifiers; 1311 with National Institutes of Health Stroke Scale score (50.2% women, 80% ischemic). Women were younger (mean age 45.4 years, men 46.9 years,

conclusionsYoung women with index strokes did not present with more milder severity strokes compared with men.

Indexed as

StrokeAdolescentAdultColoradoDatabases, FactualFemaleHumansMaleMiddle AgedRegistriesRisk FactorsSeverity of Illness IndexSex FactorsYoung Adultsex differencesstrokestroke severityyoung adults

Identifiers

PMID41744123
PMCPMC13055726

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.