ArticleJournal of extracellular vesicles2026
Varying Influence of Menstrual Cycle Phase and Hormonal Contraceptive Use on Resistance Exercise-Induced Circulating Extracellular Vesicle and Metabolite Signalling.
Article in Journal of extracellular vesicles, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06972862 (Optimizing Muscle and Bone Mechanoadaptation to Physical Training), which is not on this map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimizing Muscle and Bone Mechanoadaptation to Physical Training: Mechanistic Control Paths Via Muscle and Bone Crosstalk to Altered Mechanical Loading
Who cites it
1 citing paper in PubMed.
- Exercise‑induced exosomal noncoding RNAs: Molecular signaling cascades in bone remodeling and translational applications in sports‑related bone injuries (Review).International journal of molecular medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Resistance exercise augments circulating extracellular vesicle (EV) and metabolite signalling in manners that assist musculoskeletal and systemic adaptations. Women are often underrepresented in exercise research and recent attention has focused on whether hormonal fluctuations during the menstrual cycle and use of hormonal contraception (HC) impact exercise performance and adaptation. We investigated if menstrual phase (follicular and luteal) or HC usage (oral contraceptive pill and hormonal intrauterine device) impact the EV and metabolite response to exercise. Overall, we observed an exercise-induced response across all four groups for EV microRNAs and circulating metabolites. Women in the follicular phase had baseline differences in the most abundant miRNAs and exercise-relevant miRNAs and had the greatest miRNA response to exercise compared to other groups. Relevant metabolites were observed in EVs, but the overall response to exercise was minimally influenced by group among annotated metabolites. Multi-omic analysis showed potential presence of molecular signatures based on circulating hormone concentrations, but trends were not differentiated enough to suggest clear phenotypic differences. Overall, our data highlights unique miRNA profiles at baseline in follicular phase women but does not support the notion that circulating EV and metabolite responses to exercise are heavily influenced by menstrual cycle phase or HC use. Trial Registration: ClinicalTrials.gov identifier: NCT06972862.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.