Endothelial PAI-1 Drives Lead-Induced Cerebral Amyloid Angiopathy via Activation of C3

Huiying Gu, Cloria Luo, Yansheng Du

Abstract read

In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Huiying GuDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Cloria LuoDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Yansheng DuDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Funding

Foundation for the National Institutes of Health R21-AG 067923Foundation for the National Institutes of Health RO1-ES 027078Indiana University Bridge Grant 2284280DU

6 · The paper itself

Abstract

Environmental lead (Pb) exposure remains a significant public health concern, and its association with cerebrovascular injury and Alzheimer's disease (AD) is increasingly recognized. In this study, we demonstrated using an in vitro system that Pb exposure significantly increased the expression and release of endothelial plasminogen activator inhibitor-1 (PAI-1). A conditioned medium collected from Pb-treated endothelial cells induced the formation of complement component 3 (C3)

Indexed as

amyloid-βcerebral amyloid angiopathycomplement C3decorinleadplasminogen activator inhibitor-1 astrocyte

Identifiers

PMID41744606

DOI10.3390/biology15040297

PMCPMC12938697

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.