ArticleBiology2026
Lysolecithin Attenuates LPS-Induced Acute Liver Injury in Weaned Piglets by Inhibiting M1 Macrophage Polarization via the mTOR-Glycolysis Pathway.
Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Macrophage polarization is widely recognized as a pivotal role in the maintenance of liver homeostasis. Lysolecithin (LPC) has previously been associated with hepatoprotective effect. This study aimed to determine whether LPC protected against lipopolysaccharide (LPS)-induced liver injury by modulating macrophage polarization. Twenty-four piglets were allocated in a 2 × 2 factorial design, involving dietary supplementation (0 vs. 0.01% LPC) and immunological challenge (saline vs. LPS). Animals were euthanized 4 h post-injection, and liver tissues were harvested for analysis. Our findings showed that LPS challenge induced significant liver damage, which was ameliorated by LPC supplementation, as evidenced by improved histological and functional outcomes. LPC counteracted the LPS-induced dysregulation of mRNA expression related to macrophage polarization, including pro-inflammatory markers (
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