ESR2 Regulates Granulosa Cell Proliferation and Steroidogenesis via the PI3K/AKT/mTOR Signaling Pathway in Wuding Chickens.

Chen Li, Wei Zhu, Xinyu Ma, Xinyang Fan, Fu Ha, Yongwang Miao

Abstract read

In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Identification of Inflammatory Markers for the Prediction and Diagnosis of Diminished Ovarian Reserve Using Olink Targeted Proteomics.Journal of clinical medicine · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chen LiCollege of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.

Wei ZhuCollege of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.

Xinyu MaCollege of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.

Xinyang FanCollege of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.

Fu HaCollege of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.

Yongwang MiaoCollege of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.ORCID 0000-0003-2127-0379

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Wuding chicken, a renowned indigenous breed in Yunnan Province, is prized for its superior meat quality; however, its economic potential is limited by pronounced broodiness and suboptimal egg production. Central to alleviating these constraints is the precise regulation of ovarian granulosa cell (GC) proliferation and steroidogenic processes that dictate follicular development and laying performance. While Estrogen Receptor 2 (ESR2) is a known transcription factor implicated in follicular maturation, its spatiotemporal dynamics within the hypothalamic-pituitary-ovarian (HPO) axis and its specific regulatory mechanisms in Wuding chicken remain elusive. This study characterizes

Indexed as

ESR2genomic signaling pathwaynon-genomic signaling pathwayovarian granulosa cellsPI3K/AKT/mTORWuding chicken

Identifiers

PMID41744679

DOI10.3390/biology15040370

PMCPMC12937930

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.