ArticleBiosensors2026
Smart Clot: An Automated Point-of-Care Flow Assay for Quantitative Whole-Blood Platelet, Fibrin, and Thrombus Kinetics.
Alessandro Foladore, Simone Lattanzio, Ekaterina Baryshnikova, Martina Anguissola, Elisabetta Lombardi, Marco Valvasori, Roberto Vettori, Francesco Agostini, Roberto Tassan Toffola, Lidia Rota and 2 more
Abstract read
In one paragraphArticle in Biosensors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Alessandro FoladoreSedicidodici s.r.l., 33170 Pordenone, Italy.
Simone LattanzioSedicidodici s.r.l., 33170 Pordenone, Italy.
Ekaterina BaryshnikovaDepartment of Cardiothoracic and Vascular Anesthesia and Intensive Care, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Donato, 20097 San Donato Milanese, Italy.ORCID 0000-0001-7476-2823 Martina AnguissolaDepartment of Cardiothoracic and Vascular Anesthesia and Intensive Care, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Donato, 20097 San Donato Milanese, Italy.ORCID 0000-0002-7132-2782 Elisabetta LombardiStem Cell Unit, Department of Research and Advanced Cancer Diagnostic, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.ORCID 0000-0002-3688-9281 Marco ValvasoriStem Cell Unit, Department of Research and Advanced Cancer Diagnostic, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.
Roberto VettoriStem Cell Unit, Department of Research and Advanced Cancer Diagnostic, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.ORCID 0000-0003-1899-064X Francesco AgostiniStem Cell Unit, Department of Research and Advanced Cancer Diagnostic, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.ORCID 0000-0002-2808-9348 Roberto Tassan ToffolaUnit of Transfusion Medicine in Oncology, Department of Transfusion Medicine, Azienda Sanitaria Friuli Occidentale, 33170 Pordenone, Italy.
Lidia RotaSedicidodici s.r.l., 33170 Pordenone, Italy.
Marco RanucciDepartment of Cardiothoracic and Vascular Anesthesia and Intensive Care, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Donato, 20097 San Donato Milanese, Italy.ORCID 0000-0002-4915-3572 Mario MazzucatoStem Cell Unit, Department of Research and Advanced Cancer Diagnostic, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.ORCID 0000-0001-8319-053X Funding
Italian Ministry of Health "Bando Ricerca Finalizzata 2010" project, grant # RF-2010-2317993Regione Autonoma Friuli Venezia Giulia "POR FESR 2014-2020 Asse 1 Attività 1.3.b n.1489/2017" project, procedure # 40250/2017
6 · The paper itselfAbstract
Hemostasis depends on the coordinated interaction between platelets, coagulation factors, endothelium, and shear forces. Current point-of-care (POC) assays evaluate isolated components of haemostasis or operate under nearly static conditions, limiting their ability to reproduce physiological thrombus formation. In this study, we performed the technical validation of Smart Clot, a fully automated, microfluidic POC platform that quantifies platelet aggregation, fibrin formation, and total thrombus growth under controlled arterial shear using unmodified whole blood. Recalcified citrated blood was perfused over collagen at γ˙
Indexed as
Blood PlateletsFibrinPoint-of-Care SystemsThrombosisHumansKineticsPlatelet AggregationFibrinanticoagulantsantiplatelet therapycardiopulmonary bypassflow-based hemostasisintegrated densitymicrofluidicsplatelet–fibrin interactionspoint-of-caresmart clotthrombin generation
Identifiers
PMID41744699
PMCPMC12938410
What Socratic holds
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