Evidence map›Paper›PMID 41744731›Full record

ArticleBiosensors2026

Inkjet-Printed Electrode Enable Portable Electrochemical Immunosensing of Tau-441 for Early Alzheimer's Screening.

Binglun Li, Chenghao Liu, Chenlu Gu, Shanshan Wei, Shiyong Li, Ziang Liu, Dongdong Zhao, Qunfeng Tang, Yun Chen, Zhencheng Chen

Abstract read
In one paragraph

Article in Biosensors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Binglun LiSchool of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China.
Chenghao LiuSchool of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China.
Chenlu GuSchool of Electronic Engineering and Automation, Guilin University of Electronic Technology, Guilin 541004, China.
Shanshan WeiGuangxi Colleges and Universities Key Laboratory of Biomedical Sensors and Intelligent Instrument, Guilin 541004, China.
Shiyong LiGuangxi Colleges and Universities Key Laboratory of Biomedical Sensors and Intelligent Instrument, Guilin 541004, China.ORCID 0000-0002-0229-9259
Ziang LiuSchool of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China.
Dongdong ZhaoSchool of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China.
Qunfeng TangSchool of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China.ORCID 0000-0002-5828-1509
Yun ChenSchool of Physics and Technology, Guangxi Normal University, Guilin 541004, China.
Zhencheng ChenSchool of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China.

Funding

Central Guided Local Science and Technology Development Fund Project for Science and Technology Innovation Base Construction Guike ZY24212046Guangxi Key R&D Plan Project Guike AB23075183National Natural Science Foundation of China Joint Fund Project U22A2092
6 · The paper itself

Abstract

Early diagnosis of Alzheimer's disease represents a critical clinical challenge, and the high-sensitive biomarkers measurement holds great potential for enabling early identification and intervention. This study proposes an electrochemical immunosensing strategy based on inkjet printing for the quantitative detection of Tau-441. Conductive patterns were formed by inkjet printing, followed by surface functionalization with gold nanoparticles to immobilize highly specific anti-Tau-441. This process created a stable and high affinity immunorecognition interface that enhances electron transfer and signal amplification. Furthermore, we developed and integrated a low-power portable detection platform to achieve a rapid detection process encompassing sample loading, signal acquisition, and on-device readout. The method shows a linear response from 50 fg/mL to 10 ng/mL and a limit of detection of 16 fg/mL (S/N = 3), with high specificity and good reproducibility. By combining scalable inkjet fabrication with a self-contained handheld reader, this method shortens the path from sample to result and offers a practical route for on-site screening and early intervention in Alzheimer's disease.

Indexed as

Alzheimer’s diseaseelectrochemistryinkjet-printed electrodeportable electrochemical platformTau-441

Identifiers

PMID41744731
PMCPMC12938625

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.