Evidence map›Paper›PMID 41744764›Full record

ArticleCells2026

Myeloid GHSR Deficiency Protects Against Thermogenic Impairment in Aging Through Immune Remodeling of Brown Adipose Tissue.

Hye Won Han, Da Mi Kim, Reza Baratiboldaji, Hongying Wang, Zeyu Liu, Zheng Shen, Deepak K Jha, Tadesse Teferra, Endang M Septiningsih, Bhimanagouda Patil and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hye Won HanDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-9839-0996
Da Mi KimDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.
Reza BaratiboldajiDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.
Hongying WangDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-4543-9223
Zeyu LiuDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.ORCID 0009-0005-3416-6783
Zheng ShenDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-0523-0767
Deepak K JhaDepartment of Horticultural Sciences, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-9769-666X
Tadesse TeferraDepartment of Food Science and Technology, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0003-1977-2169
Endang M SeptiningsihDepartment of Soil & Crop Sciences, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-9481-304X
Bhimanagouda PatilDepartment of Horticultural Sciences, Texas A&M University, College Station, TX 77843, USA.
Yuxiang SunDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.

Funding

National Institute of Health AG064869National Institute of Health DK118334National Institute of Health P30ES029067United States Department of Agriculture 58-3091-1-018United States Department of Agriculture 7001445USDA 7008794
6 · The paper itself

Abstract

Thermoregulatory dysfunction is a major pathophysiological consequence of aging, affecting many elderly individuals. Growth hormone secretagogue receptor (GHSR) regulates energy homeostasis and immune function. We previously showed that global GHSR deletion improves thermogenic adaptation of brown adipose tissue (BAT) in aging, but the responsible cell type remained unclear. GHSR is expressed in macrophages, and its expression in macrophages increases with aging. Here, we studied myeloid-specific

Indexed as

agingbrown adipose tissue (BAT)ghrelingrowth hormone secretagogue receptor (GHSR)inflammationmacrophagesthermogenesis

Identifiers

PMID41744764
PMCPMC12939681

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.