Evidence map›Paper›PMID 41745458›Full record

ArticleMarine drugs2026

Fucoxanthin Induces Ferroptosis in Hypopharyngeal Carcinoma Cells by Activating the p53/SLC7A11/GPX4 Axis.

Yingxing Xie, Siyu Wang, Haofei Du, Sihan Wu, Wei Wu, Guoying Qian, Haomiao Ding, Caisheng Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yingxing XieCollege of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, China.
Siyu WangCollege of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, China.
Haofei DuCollege of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, China.ORCID 0009-0006-3911-7574
Sihan WuCollege of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, China.
Wei WuHwamei College of Life and Health Sciences, Zhejiang Wanli University, Ningbo 315100, China.
Guoying QianCollege of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, China.
Haomiao DingCollege of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, China.ORCID 0009-0001-3846-7701
Caisheng WangCollege of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, China.ORCID 0009-0008-2411-8675

Funding

College Students' Innovation and Entrepreneurship Training Program S202410876082Natural Science Foundation of Ningbo City 2023J294, 2024J249Zhejiang Provincial Top Discipline of Biological Engineering KF2022010, CX2024037
6 · The paper itself

Abstract

Fucoxanthin, a marine carotenoid abundantly derived from brown algae, has been increasingly recognized for its broad-spectrum antitumor activities; however, its role in regulating ferroptosis remains insufficiently defined. Hypopharyngeal carcinoma is a highly aggressive head and neck malignancy with limited therapeutic options, highlighting the need for novel marine-derived anticancer agents. In this study, we investigated whether fucoxanthin induces ferroptosis in human hypopharyngeal carcinoma cells (Fadu) and elucidated the underlying molecular mechanisms. Transcriptome profiling combined with in vitro validation revealed that fucoxanthin markedly upregulated heme oxygenase-1 (HO-1), leading to increased intracellular Fe

Indexed as

Amino Acid Transport System y+Antineoplastic AgentsFerroptosisHypopharyngeal NeoplasmsPhospholipid Hydroperoxide Glutathione PeroxidaseTumor Suppressor Protein p53XanthophyllsBenzothiazolesCell Line, TumorGlutathioneHeme Oxygenase-1HumansIronMembrane Potential, MitochondrialReactive Oxygen SpeciesSignal TransductionAmino Acid Transport System y+Antineoplastic AgentsBenzothiazolesfucoxanthinGlutathioneHeme Oxygenase-1HMOX1 protein, humanIronPhospholipid Hydroperoxide Glutathione PeroxidaseReactive Oxygen SpeciesSLC7A11 protein, humanTP53 protein, humanTumor Suppressor Protein p53Xanthophyllsferroptosisfucoxanthinhypopharyngeal carcinomalipid peroxidationmarine carotenoidp53/SLC7A11/GPX4 pathwayreactive oxygen species

Identifiers

PMID41745458
PMCPMC12942556

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.