ReviewJournal of functional biomaterials2026
Collagen-Based Delivery Systems for the Prevention of Alveolitis: A Narrative Review and Rationale for Biopharmaceutical Development Requirements.
Review in Journal of functional biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alveolitis remains a common postoperative complication following tooth extraction, characterized by inflammation and delayed socket healing. Collagen-based materials have shown promise in promoting tissue regeneration and reducing inflammation. This review evaluates the efficacy of collagen in the prevention of alveolitis, with a focus on the development and application of topical delivery systems such as gels and collagen sponges. Special attention is given to the local application of these systems within the extraction socket and their performance under oral conditions. The study analyzes current evidence on the pathogenesis of alveolitis, the biological properties of collagen relevant to wound healing, and pharmaceutical strategies for enhancing its clinical effectiveness. The findings support the feasibility of using biodegradable, site-specific collagen-based formulations for alveolitis prevention. Such systems may provide a prolonged therapeutic effect, stabilize blood clots, reduce microbial contamination, and support angiogenesis and osteogenesis throughout the healing process. This approach offers a promising direction for improving post-extraction management protocols in dental surgery.
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