Evidence mapPaperPMID 41745738Full record

ReviewToxins2026

Indoxyl Sulfate in the Gut-Kidney Axis: Pathophysiology and Clinical Significance in CKD-Associated Colorectal Cancer.

Hidehisa Shimizu, Toshimitsu Niwa

Abstract readReview
In one paragraph

Review in Toxins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hidehisa ShimizuFaculty of Life and Environmental Sciences, Shimane University, 1060 Nishikawatsu-cho, Matsue 690-8504, Shimane, Japan.ORCID 0000-0002-0939-0098
Toshimitsu NiwaFaculty of Medical Sciences, Shubun University, 6 Nikko-cho, Ichinomiya 491-0938, Aichi, Japan.ORCID 0000-0001-8832-498X

Funding

Ministry of Education, Culture, Sports, Science and Technology JP21H03356
6 · The paper itself

Abstract

Chronic Kidney Disease (CKD) and Colorectal Cancer (CRC) share a profound epidemiological link, supported by Mendelian randomization studies suggesting causality. This review articulates a refined Gut-Kidney Axis, focusing on the pathophysiology of indole-derived uremic toxins. CKD-induced dysbiosis drives hepatic synthesis and systemic accumulation of indoxyl sulfate, which is proposed to promote carcinogenesis via Aryl Hydrocarbon Receptor (AhR) and Akt signaling, ultimately upregulating

Indexed as

Aryl Hydrocarbon ReceptorChronic Kidney Diseasecolorectal cancerFusobacterium nucleatumgut–kidney axisindoxyl sulfateLiquid BiopsyTryptophan Metabolismtumor microenvironmenturemic toxins

Identifiers

PMID41745738
PMCPMC12944506

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.