Evidence map›Paper›PMID 41746243›Full record

ArticleJACC. Basic to translational science2026

Interleukin-18 Inhibition Aggravates Atherosclerosis in Jak2

Mojdeh Tavallaie, Cheng-Chieh Hsu, Brian D Hardaway, Huijuan Dou, Trevor Fidler, Eunyoung Kim, Sandra E Schiavone, David Ngai, Tong Xiao, Nan Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. The Twisted Tale of Interleukin-18 in Atherosclerosis.JACC. Basic to translational science · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mojdeh TavallaieDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA. Electronic address: mt3591@cumc.columbia.edu.
Cheng-Chieh HsuDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Brian D HardawayDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Huijuan DouDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Trevor FidlerCardiovascular Research Institute, University of California-San Francisco, San Francisco, California, USA.
Eunyoung KimDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Sandra E SchiavoneDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
David NgaiDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Tong XiaoDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Nan WangDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Marit WesterterpDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA; Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Alan R TallDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.

Funding

Mouse and Human Atherosclerotic TissueP01HL172741 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALAN richard TALL · 2024 to 2026
$9.5M
Cholesterol efflux, CHIP and inflammasome activationR01HL107653 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALAN richard TALL · 2011 to 2026
$7.7M
NHLBI NIH HHS P01 HL172741NHLBI NIH HHS R01 HL107653
6 · The paper itself

Abstract

Clonal hematopoiesis (CH) driven by JAK2

Indexed as

agingatherosclerosisclonal hematopoiesisIL-18 antibodytranslational medicine

Identifiers

PMID41746243
PMCPMC13031066

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.