ArticleJournal of gastroenterology2026
Severity of surgical histopathological fibrosis predicted postoperative recurrence in Crohn's disease: a multi-center retrospective cohort study.
Article in Journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Reply to "Rethinking screening strategies for non-obese individuals at risk for MASLD: a clinical perspective on metabolic vulnerability".Journal of gastroenterology · 2026Article
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Authors and funding
14 authors.
Funding
Abstract
backgroundDespite treatment advances, intestinal surgery remains common in Crohn's disease (CD), with over half of patients experiencing postoperative recurrence. Intestinal fibrosis represents a key pathological feature underlying this clinical course. This study aimed to investigate the relationship between fibrosis severity and the risk of postoperative recurrence.
methodsA multi-center retrospective cohort study included CD patients undergoing intestinal resection. Histopathological slides from lesion sites and resection margins were analyzed using Masson's trichrome staining to quantify the proportion of collagen fiber area, representing fibrosis extent. Postoperative endoscopic and clinical recurrence data were collected via electronic medical records and patient follow-up interviews. Multivariable Cox regression models estimated hazard ratios (HRs) with 95% confidence intervals (CIs) for the associations between fibrosis severity and recurrence risk.
resultsAmong 268 patients, endoscopic recurrence occurred in 84 (31.3%) and clinical recurrence in 91 (34.0%). The degree of transmural intestinal fibrosis was positively associated with postoperative endoscopic recurrence (lesion site: HR
conclusionThe severity of intestinal fibrosis in both lesion site and resection margin independently predicted an increased risk of postoperative endoscopic and clinical recurrence in CD. Histopathological fibrosis assessment may help identify high-risk individuals prone to postoperative recurrence, potentially informing personalized postoperative management strategies.
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