ArticleChemistry & biodiversity2026
Amides from Porcelia ponderosa Roots Display Efficacy In Vitro Against Intracellular Amastigotes of Trypanosoma cruzi.
Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In the present work, the MeOH extract from roots of Porcelia ponderosa R.E. Fries (Annonaceae) was subjected to several chromatographic techniques to afford three chemically related amides: N-trans-p-coumaroyltyramine (1), N-trans-caffeoyltyramine (2), and N-trans-feruloyltyramine (3). Isolated compounds were characterized by NMR and MS spectral analysis. This is the first report of compounds 1-3 in P. ponderosa, while 1 is a previously unreported metabolite from the Porcelia genus. Previous studies reported the effects of amides 1-3 on the inhibition of sterol 14-α-demethylase (CYP51), a key enzyme in the life cycle of Trypanosoma cruzi, using an in silico approach. However, no experimental evidence was conducted to prove their effects against the parasite. Based on these data and isolation of amides 1-3 from roots of P. ponderosa, these compounds were tested in vitro against the intracellular amastigotes of T. cruzi. Compounds 1 and 2, containing p-coumaroyl and caffeic moieties, displayed potent activity with EC
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