ArticleAging2026
A decline in glycolytic ATP production is the fundamental mechanism limiting lifespan; species with an optimal rate of decline over time survived.
Article in Aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glycolytic ATP production declines with age, contributing to common aging phenotypes such as reduced cell division and impaired DNA & mitochondria repair. Notably, immortal cells exhibit a metabolic profile characterized by sustained, highly active glycolytic ATP production. A key unresolved question is the underlying mechanism driving the gradual decline in glycolytic ATP production during natural aging. We have found that this can be explained by the concept that a decline in glycolytic ATP production was crucial for survival of species, and only those species with an optimal rate of reduction in glycolytic ATP production over time were selected and persisted through generational changes. Sexual reproduction generates new combination of gene pairs with abundant DNA mutations during meiosis, which provides significant advantages in adapting to environmental changes and competence over other species. However, the population of species is limited because of finite food supply in the natural world. The shift from glycolysis to aerobic metabolism increases energy efficiency and the increased energy efficiency in parent generation benefits the species by enhancing survival of parent generation at starvation conditions and limited food allocation to the offspring generation. This conceptual framework can explain the finite lifespans of organisms, significant variations in lifespan across species, cellular immortality of cancer cells, and the exceptionally long life of the naked mole rat (
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.