Evidence map›Paper›PMID 41747718›Full record

ArticleCell reports. Medicine2026

SIRT1 mediates brain metabolic and developmental consequences of methionine synthase deficiency in inborn errors of cobalamin metabolism.

Karim Matmat, Ziad Hassan, Grégory Pourié, Yaser Atlasi, Snehaa Vivienne Seal, Manon Jeandel, Carole Arnold, Sachin Luharia, Rémy Umoret, Ramia Safar and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Karim MatmatInserm UMRS 1256 N-GERE (Nutrition-Genetics, and Environmental Risks Exposure), University of Lorraine, Faculty of Medicine, 54000 Nancy, France; Inserm CIC 1434, Centre de Recherche en Biomédecine de Strasbourg, University of Strasbourg, 67000 Strasbourg, France.
Ziad HassanInserm UMRS 1256 N-GERE (Nutrition-Genetics, and Environmental Risks Exposure), University of Lorraine, Faculty of Medicine, 54000 Nancy, France.
Grégory PouriéInserm UMRS 1256 N-GERE (Nutrition-Genetics, and Environmental Risks Exposure), University of Lorraine, Faculty of Medicine, 54000 Nancy, France.
Yaser AtlasiJohnston Cancer Research Centre, Queen's University Belfast, Belfast BT9 7AE, UK.
Snehaa Vivienne SealInserm UMRS 1256 N-GERE (Nutrition-Genetics, and Environmental Risks Exposure), University of Lorraine, Faculty of Medicine, 54000 Nancy, France.
Manon JeandelInserm UMRS 1256 N-GERE (Nutrition-Genetics, and Environmental Risks Exposure), University of Lorraine, Faculty of Medicine, 54000 Nancy, France.
Carole ArnoldInserm UMRS 1256 N-GERE (Nutrition-Genetics, and Environmental Risks Exposure), University of Lorraine, Faculty of Medicine, 54000 Nancy, France; CNRS UMR 7361 IS2M (Institute of Materials Science of Mulhouse), 68057 Mulhouse, France.
Sachin LuhariaJohnston Cancer Research Centre, Queen's University Belfast, Belfast BT9 7AE, UK.
Rémy UmoretInserm UMRS 1256 N-GERE (Nutrition-Genetics, and Environmental Risks Exposure), University of Lorraine, Faculty of Medicine, 54000 Nancy, France.
Ramia SafarInserm UMRS 1256 N-GERE (Nutrition-Genetics, and Environmental Risks Exposure), University of Lorraine, Faculty of Medicine, 54000 Nancy, France.
Almut HeinkenInserm UMRS 1256 N-GERE (Nutrition-Genetics, and Environmental Risks Exposure), University of Lorraine, Faculty of Medicine, 54000 Nancy, France.
Jean-Marc AlbertoInserm UMRS 1256 N-GERE (Nutrition-Genetics, and Environmental Risks Exposure), University of Lorraine, Faculty of Medicine, 54000 Nancy, France.
Okan BaspinarInserm UMRS 1256 N-GERE (Nutrition-Genetics, and Environmental Risks Exposure), University of Lorraine, Faculty of Medicine, 54000 Nancy, France.
Justine PaoliInserm UMRS 1256 N-GERE (Nutrition-Genetics, and Environmental Risks Exposure), University of Lorraine, Faculty of Medicine, 54000 Nancy, France.
Sebastien HergalantInserm UMRS 1256 N-GERE (Nutrition-Genetics, and Environmental Risks Exposure), University of Lorraine, Faculty of Medicine, 54000 Nancy, France.
Pierre RouyerInserm UMRS 1256 N-GERE (Nutrition-Genetics, and Environmental Risks Exposure), University of Lorraine, Faculty of Medicine, 54000 Nancy, France.
Jean-Michel CamadroUniversity Paris-Cité, Institut Jacques Monod, 75205 Paris Cedex 13, France.
Laurent LignièresUniversity Paris-Cité, Institut Jacques Monod, 75205 Paris Cedex 13, France.
David CoelhoInserm UMRS 1256 N-GERE (Nutrition-Genetics, and Environmental Risks Exposure), University of Lorraine, Faculty of Medicine, 54000 Nancy, France; National Center of Inborn Errors of Metabolism, University Regional Hospital Center of Nancy, 54000 Nancy, France.
Jean-Louis GuéantInserm UMRS 1256 N-GERE (Nutrition-Genetics, and Environmental Risks Exposure), University of Lorraine, Faculty of Medicine, 54000 Nancy, France; National Center of Inborn Errors of Metabolism, University Regional Hospital Center of Nancy, 54000 Nancy, France; Joan Klein Jacobs Center for Precision Nutrition and Health, Cornell University, Ithaca, NY, USA. Electronic address: jean-louis.gueant@univ-lorraine.fr.
Rosa-Maria Guéant-RodriguezInserm UMRS 1256 N-GERE (Nutrition-Genetics, and Environmental Risks Exposure), University of Lorraine, Faculty of Medicine, 54000 Nancy, France; National Center of Inborn Errors of Metabolism, University Regional Hospital Center of Nancy, 54000 Nancy, France; Tecnologico de Monterrey, Institute for Obesity Research, Monterrey, NL, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inborn errors of vitamin B12 metabolism (IECM) resulting from impaired methionine synthase (MTR) activity cause severe cognitive and neurological deficits that remain unresponsive to conventional B12 supplementation. Using a brain-specific Mtr knockout mouse model, we identify the NAD

Indexed as

5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseBrainMetabolism, Inborn ErrorsSirtuin 1Vitamin B 12AnimalsEnergy MetabolismHippocampusHumansMiceMice, KnockoutMitochondriaNeurogenesisWnt Signaling Pathway5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseSirt1 protein, mouseSirtuin 1Vitamin B 12drug repurposingenergy metabolisminborn errors of cobalamin metabolismmethionine synthaseneurodevelopmentneurogenesisone-carbon metabolismSIRT1vitamin B12 deficiencyWnt signaling

Identifiers

PMID41747718
PMCPMC13006396

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.