Evidence mapPaperPMID 41747880Full record

ArticleMolecular metabolism2026

TRPC6 governs brown adipose thermogenesis via a BMPR2-p38 MAPK signaling axis.

Danyingzhu Xie, Ying Peng, Susu Zhang, Xudong Mai, Weiheng Wen, Ming Wang, Qiao-Ping Wang, Jia Sun

Abstract read
In one paragraph

Article in Molecular metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Danyingzhu XieDepartment of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Ying PengDepartment of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Susu ZhangDepartment of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Xudong MaiDepartment of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Weiheng WenDepartment of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Ming WangDepartment of Traditional Chinese Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China. Electronic address: wming1999@163.com.
Qiao-Ping WangLaboratory of Metabolism and Aging, School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, China; Guangdong Provincial Key Laboratory of Diabetology, Guangzhou Key Laboratory of Mechanistic and Translational Obesity Research, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China. Electronic address: wangqp7@mail.sysu.edu.cn.
Jia SunDepartment of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China. Electronic address: sunjia@smu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brown adipose tissue (BAT) thermogenesis combats obesity, but mechanisms linking calcium dynamics to thermogenic programming remain incompletely defined. Here, we identify the calcium channel TRPC6 as an essential BAT-intrinsic regulator of metabolic health. BAT-specific Trpc6 knockout (Trpc6

Indexed as

Adipose Tissue, Brownp38 Mitogen-Activated Protein KinasesThermogenesisTRPC6 Cation ChannelAnimalsDiet, High-FatEnergy MetabolismHumansMaleMAP Kinase Signaling SystemMiceMice, Inbred C57BLMice, KnockoutMitochondriaObesitySignal Transductionp38 Mitogen-Activated Protein KinasesTRPC6 Cation ChannelTrpc6 protein, mouseBrown adipose tissueObesityThermogenesisTransient receptor potential cation channel subfamily c member 6 (TRPC6)

Identifiers

PMID41747880
PMCPMC12969644

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.