ArticleClinical and translational allergy2026
T-Cell Populations in Infancy After Maternal Probiotic Supplementation to Prevent Atopic Dermatitis.
Article in Clinical and translational allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of probiotics in preventing atopic dermatitis in infants: A systematic review and meta-analysis.The Journal of international medical research · 2026Pooled it
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundIn the randomised, controlled study Probiotics in the Prevention of Allergy amongst Children in Trondheim (ProPACT), maternal probiotics given from 36 weeks pregnancy until 3 months post-delivery while breastfeeding reduced atopic dermatitis (AD) in the offspring. Previous analysis of T helper (Th) subsets indicated that the preventive effect may be partially mediated through reduced Th22 percentage at 3 months of age.
objectiveTo examine the longitudinal effects of maternal probiotics on Th1, Th2, Th17, Th22, and regulatory T cells (Treg) in offspring at 10 days and 2 years of age compared to the previously published 3 months results.
methodsPregnant women (n = 415) were randomised to take probiotic milk (Lacticaseibacillus rhamnosus GG, Bifidobacterium animalis subsp. lactis Bb-12 and Lactobacillus acidophilus La-5) or placebo, and their offspring were assessed for AD at 2 years. We analysed the children's blood collected at 10 days (n = 112) and 2 years (n = 156) for Treg and Th subsets using flow cytometry and included the results from the previously analysed 3 months samples (n = 76) in the same study to compare the three timepoints using linear mixed models.
resultsThere were no statistically significant differences between T cell populations of the children in the probiotics and placebo groups at 10 days and 2 years.
conclusionWe previously observed reduced Th22 percentage in the probiotics group at 3 months. However, since the effect was not seen earlier and did not last, it may not be the main reason for AD prevention.
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Registered trials
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