Evidence map›Paper›PMID 41748499›Full record

ArticleInternational journal of cancer2026

Metabolome analysis identified exogenous cholesterol within lipid rafts that activate the Akt/mTOR signaling pathway in epithelial ovarian cancer.

Hitomi Sakaguchi-Mukaida, Kosuke Hiramatsu, Tatsuo Masuda, Mamoru Kakuda, Satoshi Nakagawa, Tadashi Iwamiya, Shinya Matsuzaki, Tetsuji Naka, Yutaka Ueda, Tadashi Kimura and 1 more

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In one paragraph

Article in International journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hitomi Sakaguchi-MukaidaDepartment of Obstetrics and Gynecology, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.ORCID https://orcid.org/0000-0001-6564-8121
Kosuke HiramatsuDepartment of Obstetrics and Gynecology, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.ORCID https://orcid.org/0000-0001-7569-7875
Tatsuo MasudaDepartment of Obstetrics and Gynecology, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.
Mamoru KakudaDepartment of Obstetrics and Gynecology, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.
Satoshi NakagawaDepartment of Obstetrics and Gynecology, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.
Tadashi IwamiyaDepartment of Obstetrics and Gynecology, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.
Shinya MatsuzakiDepartment of Obstetrics and Gynecology, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.
Tetsuji NakaInstitute for Biomedical Sciences Molecular Pathophysiology, Iwate Medical University, Yahaba-cho, Iwate, Japan.
Yutaka UedaDepartment of Obstetrics and Gynecology, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.ORCID https://orcid.org/0000-0001-8760-6379
Tadashi KimuraSakai City Hospital Organization, Sakai, Osaka, Japan.
Michiko KodamaDepartment of Obstetrics and Gynecology, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epithelial ovarian cancer (EOC) is a highly aggressive malignancy with poor prognosis. Thus, new treatment options are needed. Recently, lipid metabolism in EOC has been highlighted. However, the specific lipid molecules activating lipid metabolism remain unclear. This study aimed to elucidate lipid metabolism in EOC and evaluate the potential of its inhibition as a therapeutic approach. We obtained high-fat diet (HFD)-fed mouse serum and performed metabolome analysis to identify lipid molecules contributing to cell proliferation of EOC. We also analyzed which signaling pathway was activated by the lipid molecule. Finally, we demonstrated the inhibition of lipid metabolism in EOC cells. HFD significantly promoted tumor growth of EOC cells in vivo, and HFD-fed mouse serum promoted EOC cell proliferation in vitro. Metabolome analysis identified cholesterol (C

Indexed as

Carcinoma, Ovarian EpithelialCholesterolMembrane MicrodomainsMetabolomeOvarian NeoplasmsProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesAnimalsCell Line, TumorCell ProliferationDiet, High-FatFemaleHumansLipid MetabolismMiceSignal TransductionCholesterolMTOR protein, humanProto-Oncogene Proteins c-aktTOR Serine-Threonine Kinasescholesterolepithelial ovarian cancerhigh‐fat dietlipid metabolismmetabolome analysis

Identifiers

PMID41748499
PMCPMC13140013

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.