Evidence map›Paper›PMID 41748557›Full record

ArticleNature communications2026

Disrupted temperature-sleep coupling mechanism in a Dravet syndrome mouse model.

Saja Fadila, Georgii Krivoshein, Hala Majadly, Anat Mavashov, Shahak Ranen, Marina Brusel, Iria G Dopeso-Reyes, Bertrand Beucher, Eric J Kremer, Else A Tolner and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Saja FadilaDepartment of Human Molecular Genetics and Biochemistry, Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Georgii KrivosheinDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-4737-5099
Hala MajadlyGoldschleger Eye Research Institute, Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Anat MavashovGoldschleger Eye Research Institute, Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Shahak RanenDepartment of Human Molecular Genetics and Biochemistry, Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Marina BruselGoldschleger Eye Research Institute, Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Iria G Dopeso-ReyesInstitut de Génétique Moléculaire de Montpellier, Université de Montpellier, CNRS, Montpellier, France.
Bertrand BeucherInstitut de Génétique Moléculaire de Montpellier, Université de Montpellier, CNRS, Montpellier, France.
Eric J KremerInstitut de Génétique Moléculaire de Montpellier, Université de Montpellier, CNRS, Montpellier, France.ORCID http://orcid.org/0000-0001-6114-7530
Else A TolnerDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Moran RubinsteinDepartment of Human Molecular Genetics and Biochemistry, Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. moranrub@tauex.tau.ac.il.ORCID http://orcid.org/0000-0003-2617-2276

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-10-INBS-04Dravet Syndrome Foundation (DSF) NAEC | European Regional Development Fund (Europski Fond za Regionalni Razvoj) FEDER-FSE 2014-2020Israel Science Foundation (ISF) 214/22
6 · The paper itself

Abstract

Dravet syndrome (DS) is associated with epilepsy, developmental delays, thermal dysregulation, and sleep disturbances. While seizures have been linked to hippocampal dysfunction, what drives sleep disturbances and thermal dysregulation is poorly understood. Using DS mice (Scn1a

Indexed as

Body Temperature RegulationEpilepsies, MyoclonicSleepAnimalsBody TemperatureDisease Models, AnimalFemaleMaleMiceMice, Inbred C57BLNAV1.1 Voltage-Gated Sodium ChannelWakefulnessNAV1.1 Voltage-Gated Sodium ChannelScn1a protein, mouse

Identifiers

PMID41748557
PMCPMC13062047

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.