Evidence map›Paper›PMID 41748572›Full record

ArticleNature communications2026

The nitrogen starvation-induced inhibitor Rts3 restrains Sit4/PP6 to gate quiescence downstream of TORC1.

Ladislav Dokládal, Marie-Pierre Péli-Gulli, Josephine Alba, Michael Stumpe, Malika Jaquenoud, Insa Klemt, Cyril Andrea Jaggi, Rebecca Lourdes Calviello, Zehan Hu, Devanarayanan Siva Sankar and 3 more

Abstract read
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In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ladislav DokládalDepartment of Biology, University of Fribourg, Fribourg, Switzerland.ORCID http://orcid.org/0000-0001-8407-9876
Marie-Pierre Péli-GulliDepartment of Biology, University of Fribourg, Fribourg, Switzerland.ORCID http://orcid.org/0000-0002-6908-7082
Josephine AlbaDepartment of Biology, University of Fribourg, Fribourg, Switzerland.ORCID http://orcid.org/0000-0002-5467-4751
Michael StumpeDepartment of Biology, University of Fribourg, Fribourg, Switzerland.ORCID http://orcid.org/0000-0002-9443-9326
Malika JaquenoudDepartment of Biology, University of Fribourg, Fribourg, Switzerland.ORCID http://orcid.org/0009-0003-3615-1097
Insa KlemtDepartment of Biology, Institute of Biochemistry, Eidgenössische Technische Hochschule (ETH), Zürich, Switzerland.ORCID http://orcid.org/0000-0002-9115-1132
Cyril Andrea JaggiDepartment of Biology, University of Fribourg, Fribourg, Switzerland.ORCID http://orcid.org/0009-0007-4362-6547
Rebecca Lourdes CalvielloDepartment of Biology, University of Fribourg, Fribourg, Switzerland.ORCID http://orcid.org/0009-0007-8710-4556
Zehan HuDepartment of Biology, University of Fribourg, Fribourg, Switzerland.ORCID http://orcid.org/0000-0001-6182-4781
Devanarayanan Siva SankarDepartment of Biology, University of Fribourg, Fribourg, Switzerland.ORCID http://orcid.org/0009-0000-3133-7691
Matthias PeterDepartment of Biology, Institute of Biochemistry, Eidgenössische Technische Hochschule (ETH), Zürich, Switzerland.ORCID http://orcid.org/0000-0002-2160-6824
Jörn DengjelDepartment of Biology, University of Fribourg, Fribourg, Switzerland.ORCID http://orcid.org/0000-0002-9453-4614
Claudio De VirgilioDepartment of Biology, University of Fribourg, Fribourg, Switzerland. Claudio.DeVirgilio@unifr.ch.ORCID http://orcid.org/0000-0001-8826-4323

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 184671, 214824, 212187, 229588, 200426, 236080
6 · The paper itself

Abstract

Cellular quiescence is a reversible state essential for survival under nutrient-limiting or growth-restrictive conditions, yet the mechanisms fine-tuning its depth and reversibility remain elusive. Here, we identify Saccharomyces cerevisiae Rts3 as a regulator of the quiescence trajectory downstream of TORC1. Using phosphatase inhibitor beads and mass spectrometry, we characterize Rts3 as a phosphatase interactor in rapamycin-treated cells and define it as an inhibitor of the PP6 phosphatase Sit4. Mechanistically, it employs an α-helix to dock directly into the Sit4-Sap185/190 catalytic cleft. Transcriptionally induced by Gln3/Gat1 during nitrogen starvation, Rts3 is rapidly degraded upon nutrient repletion via a TORC1-SCF

Indexed as

Mechanistic Target of Rapamycin Complex 1NitrogenPhosphoprotein PhosphatasesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsGATA Transcription FactorsGene Expression Regulation, FungalProtein Phosphatase 2SirolimusTranscription FactorsGAT1 protein, S cerevisiaeGATA Transcription FactorsGLN3 protein, S cerevisiaeMechanistic Target of Rapamycin Complex 1NitrogenPhosphoprotein PhosphatasesProtein Phosphatase 2Saccharomyces cerevisiae ProteinsSirolimusSIT4 protein, S cerevisiaeTORC1 protein complex, S cerevisiaeTranscription Factors

Identifiers

PMID41748572
PMCPMC13062003

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.