Evidence mapPaperPMID 41748778Full record

ArticleScientific reports2026

Association of Life's Essential 8 with albuminuria in a Northern Chinese population: a cross-sectional study.

Ziyue Man, Shimeng Zhang, Guilin Hu, Teng Zhang, Jianjun Mu, Yueyuan Liao

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Ziyue ManDepartment of Cardiology, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, China.
Shimeng ZhangDepartment of Cardiology, Second People's Hospital of Shaanxi Province, Xi'an, China.
Guilin HuDepartment of Cardiology, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, China.
Teng ZhangDepartment of Cardiology, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, China.
Jianjun MuDepartment of Cardiology, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, China. mujjun@163.com.
Yueyuan LiaoDepartment of Imaging, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China. lyy931002@163.com.

Funding

the Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University XJTU1AF-CRF-2023-004the International Joint Research Center for Cardiovascular Precision Medicine of Shaanxi Province 2020GHJD-14the Key Research and Development Program of Shaanxi 2023-ZDLSF-50the National Natural Science Foundation of China No. 82070437the National Natural Science Foundation of China No. 82300502
6 · The paper itself

Abstract

Albuminuria is strongly associated with the development and progression of cardiovascular disease. We aimed to investigate the association between Life's Essential 8 (LE8) and albuminuria. The cross-sectional study enrolled 8,648 adults and excluded individuals with incomplete LE8 index data, missing serum creatinine or albumin/creatinine ratio data, and a diagnosis of chronic kidney disease. Albuminuria was defined as urinary albumin to creatinine ratio (uACR) ≥ 30 mg/g. According to the recommendation of the American Heart Association (AHA), the LE8 score was categorized into three groups: high cardiovascular health (CVH), medium CVH, and low CVH. To evaluate the relationship between LE8 and albuminuria, logistic regression and restricted cubic spline models were employed. Of the 8,648 participants, 949 (11.0%) had albuminuria. After adjusting for potential confounding factors, compared with the low CVH group, the moderate CVH group (odds ratio: 0.552; 95% confidence interval: 0.388 to 0.786; P = 0.001) and high CVH group (OR: 0.253; 95%CI: 0.173 to 0.372; P < 0.001) showed a significant lower odds of albuminuria, and a significant linear negative association between LE8 scores and uACR levels was observed, as well as a non-linear connection between LE8 score and albuminuria. The prevalence of albuminuria was greater among female individuals across all CVH groups compared to their male counterparts. The LE8 scores exhibited a negative correlation with albuminuria levels. Adhering to optimal cardiovascular health is associated with better kidney health.

Indexed as

AlbuminuriaAdultAgedCardiovascular DiseasesChinaCreatinineCross-Sectional StudiesEast Asian PeopleFemaleHumansMaleMiddle AgedRisk FactorsCreatinineAlbuminuriaCardiovascular healthLife’s essential 8Sex difference

Identifiers

PMID41748778
PMCPMC13043696

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.