ArticleBrain imaging and behavior2026
Vertexwise Cortical Deviation Mapping (VCDM): A precision approach to cortical thickness assessment in non-affective psychosis.
Article in Brain imaging and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundSchizophrenia is associated with structural brain abnormalities, particularly in cortical thickness and gray matter volume. However, despite consistent group-level findings, these measures have had limited clinical utility due to regional variability and the lack of individualized reference frameworks.
methodsStructural MRI data were obtained from 1,343 individuals across three cohorts: the Human Connectome Project Young Adult (HCP-YA), Early Psychosis (HCP-EP) and a similar mixed cohort (BRAINS). Cortical thickness was assessed in healthy control (CON, n = 1206) and non-affective psychosis (NAP, n = 137) subjects using FreeSurfer and Vertexwise Cortical Deviation Mapping (VCDM) across 298,000 cortical vertices to identify deviations exceeding ± 2 standard deviations from age-adjusted normative values. Group differences and clinical correlations were evaluated using ANOVA and regression analyses. Heritability estimates for deviation metrics were derived from monozygotic and dizygotic twin data.
resultsNAP participants showed significant global cortical thinning compared to controls, with moderate effect sizes (d = 0.53–0.58). Vertex-wise analyses revealed substantially higher percentages of very thin cortical (pTHIN) vertices in NAP (left: d = 1.09; right: d = 1.25), while the percentage of very thick vertices (pTHICK) did not differ by group. Regional analyses of frontal and temporal cortices did not yield improved group differentiation. Clinical symptom severity (e.g., PANSS-positive, SANS scores) predicted higher pTHIN in NAP, while cognitive performance (e.g., working memory, vocabulary) was associated with pTHICK in both groups. Vertex-wise deviation metrics were found to be highly heritable, with heritability estimates of 0.86 (pTHIN) and 0.80 (pTHICK).
conclusionVCDM offers a sensitive, individualized method for detecting cortical abnormalities in psychosis, with stronger effect sizes and broader spatial resolution than traditional approaches. It may support more precise diagnosis, prognosis, and treatment monitoring in clinical settings.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.