Evidence map›Paper›PMID 41748895›Full record

ArticleJournal of hematopathology2026

The importance of bone marrow biopsy for chronic myeloid leukemia classification-a case report.

Natália Vital Gonçalves, Herton Luiz Alves Sales Filho, João Paulo Cabral de Magalhães Gomes, Guilherme Brasil Duffles Amarante, Gislaine Borba de Oliveira, Irene Lorand-Metze, Kátia Borgia Barbosa Pagnano, Guilherme Rossi Assis-Mendonça

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In one paragraph

Article in Journal of hematopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Natália Vital GonçalvesDivision of Anatomic Pathology, Department of Pathology, School of Medical Sciences, University of Campinas (Unicamp), Campinas, Brazil.
Herton Luiz Alves Sales FilhoCentro de Hematologia e Hemoterapia (Hemocentro-UNICAMP), Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.
João Paulo Cabral de Magalhães GomesCentro de Hematologia e Hemoterapia (Hemocentro-UNICAMP), Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.
Guilherme Brasil Duffles AmaranteCentro de Hematologia e Hemoterapia (Hemocentro-UNICAMP), Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.
Gislaine Borba de OliveiraCentro de Hematologia e Hemoterapia (Hemocentro-UNICAMP), Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.
Irene Lorand-MetzeCentro de Hematologia e Hemoterapia (Hemocentro-UNICAMP), Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.
Kátia Borgia Barbosa PagnanoCentro de Hematologia e Hemoterapia (Hemocentro-UNICAMP), Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.
Guilherme Rossi Assis-MendonçaDivision of Anatomic Pathology, Department of Pathology, School of Medical Sciences, University of Campinas (Unicamp), Campinas, Brazil. grassis@unicamp.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the BCR::ABL1 rearrangement, usually diagnosed by data of peripheral blood, bone marrow cytology, cytogenetics, and the detection of the BCR:ABL1 rearrangement. An accurate diagnosis, including the precise phase of the disease, is essential to guide appropriate treatment. We present the case of a patient admitted at our Institution with the hypothesis of CML in chronic phase, based on clinical and bone marrow cytological findings. Bone marrow biopsy showed some areas with morphologic features of CML in chronic phase but also sheets of B lymphoblasts, compatible with lymphoid blast crisis. Flow cytometry detected 1.18% of lymphoblasts. This report clearly illustrates the importance of the examination of bone marrow by several techniques. It highlights the importance of the biopsy in recognizing anomalous immunomorphological patterns, which can lead to diagnostic and therapeutic changes in CML.

Indexed as

Bone MarrowLeukemia, Myelogenous, Chronic, BCR-ABL PositiveBiopsyBlast CrisisHumansBiopsyBone marrowChronic myeloid leukemiaHistologyLymphoid blast crisis

Identifiers

PMID41748895
PMCPMC12946378

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.