Evidence map›Paper›PMID 41748905›Full record

ArticleGenes and immunity2026

Immunoglobulin gene polymorphisms shape the naïve B-cell receptor repertoire; relevance to celiac disease.

Aengus Officer, Corey T Watson, Eric Engelbrecht, Shiva Dahal-Koirala, Louise F Risnes, Knut E A Lundin, Eivind Ness-Jensen, Ida Lindeman, Ludvig M Sollid

Abstract read
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In one paragraph

Article in Genes and immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aengus OfficerNorwegian Coeliac Disease Research Centre, University of Oslo, Oslo, Norway. aengus.officer@medisin.uio.no.ORCID 0009-0006-6799-8751
Corey T WatsonDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Louisville, Louisville, KY, USA.ORCID 0000-0001-7248-8787
Eric EngelbrechtDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Louisville, Louisville, KY, USA.ORCID 0000-0002-4122-3425
Shiva Dahal-KoiralaInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Louise F RisnesNorwegian Coeliac Disease Research Centre, University of Oslo, Oslo, Norway.
Knut E A LundinNorwegian Coeliac Disease Research Centre, University of Oslo, Oslo, Norway.
Eivind Ness-JensenHUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.ORCID 0000-0001-6005-0729
Ida Lindeman *Norwegian Coeliac Disease Research Centre, University of Oslo, Oslo, Norway.ORCID 0000-0001-8343-2842
Ludvig M Sollid *Norwegian Coeliac Disease Research Centre, University of Oslo, Oslo, Norway. l.m.sollid@medisin.uio.no.ORCID 0000-0001-8860-704X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic variation in the loci encoding immunoglobulin genes (IGH, IGK and IGL) affects the repertoire of B-cell receptors (BCRs). Such effects were previously demonstrated for total peripheral blood B cells, but so far have not been investigated at scale for isolated naïve B cells. As B cells are implicated in the pathogenesis of autoimmune diseases, genetically encoded features of the naïve BCR repertoire may affect disease risk, for instance in celiac disease (CeD) which is hallmarked by stereotyped disease-specific antibodies that recognize antigen in their germline configuration. Here we have characterized the BCR repertoire of naïve B cells in 102 individuals with CeD and 102 control subjects by undertaking gene usage quantitative trait loci analyses based on repertoire sequencing and single nucleotide polymorphism genotyping. Variants within each of the loci had significant effects on the naïve BCR repertoires, with the usage of 80% of IGH genes, 54% of IGK genes and 84% of IGL genes being significantly affected by gene polymorphisms. Effects of genetic polymorphisms on BCR usage were observed for genes implicated in stereotypic responses previously associated with CeD, yet no strong evidence for CeD predisposing effects of polymorphisms within the IGH, IGK and IGL loci was uncovered.

Indexed as

Celiac DiseaseGenes, ImmunoglobulinPolymorphism, Single NucleotideReceptors, Antigen, B-CellB-LymphocytesHumansQuantitative Trait LociReceptors, Antigen, B-Cell

Identifiers

PMID41748905

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.