ReviewNaunyn-Schmiedeberg's archives of pharmacology2026
Global trends, knowledge structure, and thematic evolution of statin-cancer research: A comprehensive mapping and visualization study with insights from highly cited literature (1940-2025).
Review in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Statins have attracted increasing attention beyond cardiovascular prevention due to their potential anticancer effects; however, the intellectual structure and long-term evolution of statin-cancer research remain insufficiently characterized. This study aimed to systematically map the global development, thematic architecture, and collaborative landscape of statin-cancer research using bibliometric approaches. A total of 6100 article-type publications indexed in the Scopus database from 1940 to 2025 were analyzed using Bibliometrix and VOSviewer. Analyses included descriptive metrics, logistic growth modeling, geographic and institutional mapping, international collaboration networks, Bradford's Law of journal scattering, co-citation analysis, keyword dynamics, thematic evolution, and N-gram trend analysis. The field demonstrated sustained growth (annual growth rate 7.36%) and has recently entered a consolidation phase, supported by strong international collaboration and a stable core of high-impact journals, institutions, and scholars. Thematic analyses revealed a clear shift from cardiovascular and mechanistic foundations toward oncology-driven, drug-specific, and translational research, with breast cancer emerging as a dominant focus and simvastatin forming a highly developed niche theme. Emerging trends highlighted increasing emphasis on physiologically based pharmacokinetic modeling, drug-drug interactions, and clinical safety considerations. Overall, this study provides a comprehensive, data-driven overview of statin-cancer research, offering strategic insights to guide future experimental, clinical, and translational investigations.
Indexed as
Identifiers
41748945What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.