Evidence map›Paper›PMID 41749232›Full record

ArticleAIDS research and therapy2026

Immune and hematologic alterations associated with CD4

Zakaria Elkodmiri, Abdelmouine Salami, Moulay Yassine Belghali, Rajaa Hazime, Fatima-Ezzohra Eddehbi, Saad Lamjadli, Salma Rouhi, Wafaa Qiddi, Sanaa Sayagh, Malika Idalene and 4 more

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Article in AIDS research and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zakaria ElkodmiriImmunopathology-Immunotherapy-Immunomonitoring Laboratory, Faculty of Medicine, Mohammed VI University of Health and Sciences (UM6SS), Casablanca, Morocco. zelkodmiri@um6ss.ma.
Abdelmouine SalamiLaboratory of Immunology, Center of Clinical Research, Mohammed VI University Hospital, Marrakech, Morocco.
Moulay Yassine BelghaliLaboratory of Immunology, Center of Clinical Research, Mohammed VI University Hospital, Marrakech, Morocco.
Rajaa HazimeLaboratory of Immunology, Center of Clinical Research, Mohammed VI University Hospital, Marrakech, Morocco.
Fatima-Ezzohra EddehbiLaboratory of Immunology, Center of Clinical Research, Mohammed VI University Hospital, Marrakech, Morocco.
Saad LamjadliLaboratory of Immunology, Center of Clinical Research, Mohammed VI University Hospital, Marrakech, Morocco.
Salma RouhiLaboratory of Hematology, Faculty of Medicine and Pharmacy, Mohammed VI University Hospital, Cadi Ayyad University, Marrakech, Morocco.
Wafaa QiddiLaboratory of Hematology, Faculty of Medicine and Pharmacy, Mohammed VI University Hospital, Cadi Ayyad University, Marrakech, Morocco.
Sanaa SayaghLaboratory of Hematology, Faculty of Medicine and Pharmacy, Mohammed VI University Hospital, Cadi Ayyad University, Marrakech, Morocco.
Malika IdaleneDepartment of Infectious Diseases, Faculty of Medicine and Pharmacy, Mohammed VI University Hospital, Cadi Ayyad University, Marrakech, Morocco.
Maryame AhnachImmunopathology-Immunotherapy-Immunomonitoring Laboratory, Faculty of Medicine, Mohammed VI University of Health and Sciences (UM6SS), Casablanca, Morocco.
Noura TassiDepartment of Infectious Diseases, Faculty of Medicine and Pharmacy, Mohammed VI University Hospital, Cadi Ayyad University, Marrakech, Morocco.
Bouchra GhaziImmunopathology-Immunotherapy-Immunomonitoring Laboratory, Faculty of Medicine, Mohammed VI University of Health and Sciences (UM6SS), Casablanca, Morocco.
Brahim AdmouLaboratory of Immunology, Center of Clinical Research, Mohammed VI University Hospital, Marrakech, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HIV infection profoundly impacts both the immune and hematologic systems. This retrospective study aimed to assess the effect of CD4+ T-cell depletion on peripheral immune and hematologic cell populations in 1293 people living with HIV (PLWH). Patients with CD4+ counts < 200 cells/µL exhibited significant reductions in neutrophils (4000 ± 1200 cells/µL), eosinophils (150 ± 50 cells/µL), basophils (30 ± 10 cells/µL), monocytes (300 ± 100 cells/µL), erythrocytes (4.3 ± 0.6 × 106/µL), and platelets (268 ± 78 × 103/µL). As evaluated in 93 PLWH cases, B cells showed a similar trend (150 ± 50 cells/µL), while the decrease of NK cells was not significant (200 ± 70 cells/µL),. In parallel, we observed a compensatory increase in CD8+ T lymphocytes (850 ± 300 cells/µL). These findings highlight the complex interplay between CD4+ T-cell depletion and both immune and hematologic cells in the context of HIV infection, which emphasizes the need for integrated monitoring to inform targeted interventions and optimize clinical outcomes.

Indexed as

CD4-Positive T-LymphocytesHIV InfectionsLymphocyte DepletionAdultCD4 Lymphocyte CountCD8-Positive T-LymphocytesCytopeniaFemaleHumansImmunophenotypingMaleMiddle AgedMoroccoRetrospective StudiesCBCCD4 + T-cell depletionHematological changesImmunophenotyping, flow cytometryPeople living with HIV

Identifiers

PMID41749232
PMCPMC13040705

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.